Hembury Thomas A, Lee Benita, Gascoyne Randy D, Macpherson Nicol, Yang Bin, House Nancy, Medeiros L Jeffrey, Hsi Eric D
Department of Clinical Pathology, Cleveland Clinic Foundation, OH 44195, USA.
Am J Clin Pathol. 2002 Apr;117(4):574-80. doi: 10.1309/edal-r8ha-u3el-t37d.
Primary cutaneous diffuse large B-cell lymphoma (DLBCL) is an uncommon lymphoma. Some authors have suggested that large B-cell lymphoma can be segregated based on anatomic site, with tumors of the lower extremity being unique. We report 15 cases of primary cutaneous DLBCL. Each case was analyzed immunohistochemically using antibodies specific for CD3, CD5, CD10, CD20, bcl-2, bcl-6, and p53. Polymerase chain reaction analysis for t(14;18)(q32;q21) also was performed. There were 13 men and 2 women (median age, 64 years). Thirteen tumors were composed predominantly of centroblasts, and 2 were immunoblastic. There was a median follow-up of 72 months. Of the 4 patients with primary cutaneous DLBCL of the lower extremity (thigh, knee, leg), 2 (50%) experienced a recurrence and 1 patient died of disease. In the non-lower extremity cases, 18% (2/11) recurred and no patients died of disease. We conclude that primary cutaneous DLBCL usually occurs in elderly patients with a male predominance. Recurrences are common, but death of disease is rare.
原发性皮肤弥漫性大B细胞淋巴瘤（DLBCL）是一种罕见的淋巴瘤。一些作者认为，大B细胞淋巴瘤可根据解剖部位进行分类，其中下肢肿瘤具有独特性。我们报告了15例原发性皮肤DLBCL病例。每例病例均使用针对CD3、CD5、CD10、CD20、bcl-2、bcl-6和p53的特异性抗体进行免疫组化分析。还进行了t(14;18)(q32;q21)的聚合酶链反应分析。患者中有13名男性和2名女性（中位年龄64岁）。13个肿瘤主要由中心母细胞组成，2个为免疫母细胞性。中位随访时间为72个月。在4例下肢（大腿、膝盖、小腿）原发性皮肤DLBCL患者中，2例（50%）复发，1例患者死于该疾病。在非下肢病例中，18%（2/11）复发，无患者死于该疾病。我们得出结论，原发性皮肤DLBCL通常发生在老年男性患者中。复发很常见，但死于该疾病的情况很少见。
