dos Santos Claudia C, Zhang Haibo, Slutsky Arthur S
University of Toronto, Ontario, Canada.
Crit Care. 2002 Feb;6(1):4-6. doi: 10.1186/cc1443. Epub 2002 Jan 11.
The recognition that neutrophils, macrophages, and other components of the inflammatory cascade participate in the generation and progression of acute lung injury/acute respiratory distress syndrome has resulted in the use of anti-inflammatory agents in an attempt to attenuate this inflammatory response and to prevent further progression of the acute lung injury. The recent finding that cytokines, in part mediators of this 'overwhelming' inflammatory reaction, may also stimulate bacterial growth, impair bacterial clearance, and promote the subsequent development of nosocomial infections may have important implications to the management of the acute lung injury/acute respiratory distress syndrome patient.
认识到中性粒细胞、巨噬细胞和炎症级联反应的其他成分参与急性肺损伤/急性呼吸窘迫综合征的发生和发展，促使人们使用抗炎药物来试图减轻这种炎症反应，并防止急性肺损伤的进一步发展。最近的研究发现，细胞因子作为这种“过度”炎症反应的部分介质，可能还会刺激细菌生长、损害细菌清除，并促进随后医院感染的发生，这可能对急性肺损伤/急性呼吸窘迫综合征患者的管理具有重要意义。
