Milstein Victor, Small Joyce G., Klapper Marietta H., Small Iver F., Miller Marvin J., Kellams Jeffrey J.
Larue D. Carter Memorial Hospital and Indiana University School of Medicine, Indianapolis, Indiana, USA.
Convuls Ther. 1987;3(1):1-9.
Recent reports have challenged the assumption that unilateral and bilateral electroconvulsive therapy (ECT) are equally effective in all cases. In a prospective study, hospitalized manic patients were randomly assigned to treatment with either lithium or ECT. The first six patients received nondominant unilateral treatment but failed to respond. However, they rapidly remitted when switched to bilateral ECT. Accordingly, the next 11 manic patients to receive ECT were assigned to bilateral treatment. They were compared with the first six patients on weekly ratings of mania and other psychopathology. Both ECT groups improved but therapeutic responses were delayed until after switchover to bilateral treatment in the patients who began with unilateral ECT. We conclude that patients in the manic state should receive bilateral rather than unilateral ECT.
近期报告对单侧和双侧电休克治疗（ECT）在所有情况下均同样有效的假设提出了质疑。在一项前瞻性研究中，住院的躁狂症患者被随机分配接受锂盐治疗或ECT治疗。前6名患者接受非优势侧单侧治疗，但无反应。然而，当转换为双侧ECT治疗时，他们迅速康复。因此，接下来接受ECT治疗的11名躁狂症患者被分配接受双侧治疗。根据每周对躁狂症和其他精神病理学的评分，将他们与前6名患者进行比较。两个ECT治疗组均有改善，但开始接受单侧ECT治疗的患者直到转换为双侧治疗后治疗反应才出现延迟。我们得出结论，处于躁狂状态的患者应接受双侧ECT治疗而非单侧ECT治疗。
