Zhang Xuejun, Wang Hongyan, Te-Shao Hsu, Yang Sen, Chen Shanyu
Institute of Dermatology, Anhui Medical University, Hefei, China.
Int J Dermatol. 2002 Oct;41(10):663-9. doi: 10.1046/j.1365-4362.2002.01596.x.
The aim of this study was to explore the effects of genetic factors on the onset of psoriasis vulgaris and to develop a possible genetic model of psoriasis in Chinese Han.
Data for 1043 patients with psoriasis vulgaris were obtained by questionnaire. Complex segregation analysis and heritability were performed using Penrose's method, Falconer's method, and the EPI INFO 6.0 and SAGE-REGTL programs.
(1) For male and female patients, the peak ages of initial onset were 30-39 and 10-19 years, respectively, with the mean age of initial onset being 27.69 +/- 12.32 years in males and 23.26 +/- 12.56 years in females. (2) Of 1043 patients with psoriasis, 326 (31.26%) were reported to have a family history of psoriasis. The onset for males with a family history of psoriasis was earlier than that for those without a family history (P < 0.01). The morbidities of first-degree relatives were 7.67% in patients with type I psoriasis and 5.27% in patients with type II (P < 0.01), and those of second-degree relatives were 1.04% in type I and 0.24% in type II (P < 0.01). (3) The onset of psoriasis was earlier in females than in males in type I psoriasis (P < 0.01), but this was not the case in type II (P > 0.05). (4) The prevalence of psoriasis in first- and second-degree relatives of the proband with psoriasis was 7.24 and 0.95%, respectively; higher than that in the general population (0.146%). (5) The heritability of psoriasis in first- and second-degree relatives was 67.04 and 46.59%, respectively. The Mendelian, no-major-gene and environment model was rejected by complex segregation analysis.
Psoriasis vulgaris follows a pattern of polygenetic or multifactorial inheritance rather than single-gene inheritance.
本研究旨在探讨遗传因素对寻常型银屑病发病的影响，并建立中国汉族人群中银屑病可能的遗传模型。
通过问卷调查获取1043例寻常型银屑病患者的数据。使用彭罗斯方法、法尔科纳方法以及EPI INFO 6.0和SAGE - REGTL程序进行复杂分离分析和遗传度计算。
（1）男性和女性患者的初发高峰年龄分别为30 - 39岁和10 - 19岁，男性初发平均年龄为27.69±12.32岁，女性为23.26±12.56岁。（2）在1043例银屑病患者中，326例（31.26%）有银屑病家族史。有家族史的男性患者发病早于无家族史者（P < 0.01）。Ⅰ型银屑病患者一级亲属发病率为7.67%，Ⅱ型为5.27%（P < 0.01）；二级亲属发病率Ⅰ型为1.04%，Ⅱ型为0.24%（P < 0.01）。（3）Ⅰ型银屑病女性发病早于男性（P < 0.01），Ⅱ型则不然（P > 0.05）。（4）银屑病先证者的一级和二级亲属中银屑病患病率分别为7.24%和0.95%；高于一般人群（0.146%）。（5）一级和二级亲属中银屑病的遗传度分别为67.04%和46.59%。复杂分离分析排除了孟德尔、无主基因和环境模型。
寻常型银屑病遵循多基因或多因素遗传模式而非单基因遗传。
