敌敌畏中毒与胃液分泌
Dichlorvos intoxication and gastric secretion.
作者信息
Maśliński S, Ciurzyńska G, Maślińska D
出版信息
Acta Physiol Pol. 1979 Sep-Dec;30(5-6):657-60.
Gastric acid secretion, pepsin concentration in gastric juice and acetylcholinesterase and histidine decarboxylase activities in gastric mucosa of rats treated with dichlorvos (DDVP) were investigated. The increase of HCl secretion, the decrease of acetylcholinesterase activity and enhanced activity of histidine decarboxylase were observed. It is suggested that a higher gastric acid secretion is secondary to histamine production in gastric mucosa, induced by acetylcholine yields gastrin yields histidine decarboxylase mechanism.
研究了用敌敌畏（DDVP）处理的大鼠胃酸分泌、胃液中胃蛋白酶浓度以及胃黏膜中乙酰胆碱酯酶和组氨酸脱羧酶活性。观察到盐酸分泌增加、乙酰胆碱酯酶活性降低以及组氨酸脱羧酶活性增强。提示胃酸分泌增加继发于胃黏膜中组胺的产生，其由乙酰胆碱产生胃泌素进而产生组氨酸脱羧酶机制诱导。
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