Jenks Christopher W
Nat Prod Lett. 2002 Feb;16(1):71-6. doi: 10.1080/1057563029001/4881.
The root bark of Tabernanthe iboga contains ibogaine as its predominant alkaloid and has been an important source of it. Ibogaine is used experimentally to interrupt drug addiction and allow therapeutic intervention, but is currently unaffordable to doctors in less economically developed countries. To meet this need, an extraction of alkaloids from T. iboga root bark was optimized and simplified to use only diluted vinegar and ammonia, and was successfully applied to related alkaloids from Voacanga africana bark also. The alkaloids were converted to their hydrochlorides and purified, and the minor alkaloids were recovered.
伊博格（Tabernanthe iboga）的根皮含有伊波加因作为其主要生物碱，一直是伊波加因的重要来源。伊波加因被用于实验中以中断药物成瘾并进行治疗干预，但目前在经济欠发达国家，医生难以负担得起。为满足这一需求，对从伊博格根皮中提取生物碱的方法进行了优化和简化，仅使用稀释的醋和氨水，并成功应用于非洲沃坎加（Voacanga africana）树皮中的相关生物碱提取。生物碱被转化为盐酸盐并进行纯化，次要生物碱也得以回收。
