Jones Rebecca L, Salamonsen Lois A, Findlay Jock K
Prince Henry's Institute of Medical Research, PO Box 5152, VIC 3168, Clayton, Australia.
Trends Endocrinol Metab. 2002 May-Jun;13(4):144-50. doi: 10.1016/s1043-2760(01)00559-8.
The human endometrium is a remarkably dynamic tissue, undergoing cycles of proliferation, differentiation and breakdown every 28 days. In preparation for embryo implantation, the endometrium differentiates or decidualizes, involving widespread morphological and functional differentiation of endometrial stromal cells. If pregnancy occurs, the decidua regulates trophoblast invasion and forms the maternal component of the placenta. Uterine remodeling has long been known to be regulated by the ovarian steroid hormones 17beta-estradiol and progesterone; however, only recently has the importance of paracrine factors in mediating the cellular and biochemical changes been recognized. Many growth factors and cytokines, such as inhibins and activins, whose expression is generally limited to developmental and pathological states, are produced by actively remodeling endometrial cells, and play crucial roles in regulating endometrial cell function. Here, we present evidence for integral roles for the inhibin and activin family in the paracrine regulation of endometrial receptivity, decidualization and implantation.
人类子宫内膜是一种极具动态性的组织，每28天经历一次增殖、分化和分解的循环。为准备胚胎着床，子宫内膜会进行分化或蜕膜化，这涉及子宫内膜基质细胞广泛的形态和功能分化。如果发生妊娠，蜕膜会调节滋养层细胞的侵入并形成胎盘的母体部分。长期以来已知子宫重塑受卵巢甾体激素17β - 雌二醇和孕酮调节；然而，直到最近旁分泌因子在介导细胞和生化变化中的重要性才被认识到。许多生长因子和细胞因子，如抑制素和激活素，其表达通常局限于发育和病理状态，由积极重塑的子宫内膜细胞产生，并在调节子宫内膜细胞功能中起关键作用。在此，我们提供证据表明抑制素和激活素家族在旁分泌调节子宫内膜容受性、蜕膜化和着床中起不可或缺的作用。
