Roy E J, Wade G N
J Comp Physiol Psychol. 1975 Aug;89(6):573-9. doi: 10.1037/h0077436.
Three experiments tested the hypothesis that testosterone may be aromatized to an estrogen to stimulate running-wheel activity in rats. Aromatizable (testosterone propionate: TP) and nonaromatizable (dihydrotestosterone propionate; DHTP) androgens were compared with estradiol benzoate (EB) for the ability to induce running in castrated male rats. The DHTP had no effect on running. The TP increased running, but EB was more than 100 times as effective. A relatively small dose of a specific estrogen antagonist, MER-25, was shown to attenuate the effects of both EB and TP on male running. The MER-25 did not affect the running of castrated, oil-treated male rats and did not inhibit the running induced by food deprivation.
三项实验对睾酮可能被芳香化为雌激素以刺激大鼠转轮活动这一假说进行了验证。将可芳香化的（丙酸睾酮：TP）和不可芳香化的（丙酸双氢睾酮；DHTP）雄激素与苯甲酸雌二醇（EB）相比较，以观察它们在去势雄性大鼠中诱导跑步的能力。DHTP对跑步没有影响。TP可增加跑步量，但EB的效果要比TP强100倍以上。结果显示，相对小剂量的一种特定雌激素拮抗剂MER - 25可减弱EB和TP对雄性大鼠跑步的影响。MER - 25对接受油处理的去势雄性大鼠的跑步没有影响，也不抑制因食物剥夺诱导的跑步。
