Premgamone A, Sriboonlue P, Disatapornjaroen W, Maskasem S, Sinsupan N, Apinives C
Department of Community Medicine, Faculty Medicine, Khon Kaen University, Thailand.
Southeast Asian J Trop Med Public Health. 2001 Sep;32(3):654-60.
The study was performed to compare the efficacy of a herbal plant, Orthosiphon grandiflorus (OG), and the drug sodium potassium citrate (SPC) in treatment of renal calculi. Forty-eight rural stone formers identified by ultrasonography were recruited and randomly assigned to two treatment groups (G1 and G2). For a period up to 18 months, subjects in G1 received 2 cups of OG tea daily, each tea cup made from an OG tea bag (contained 2.5 g dry wt), and G2 received 5-10 g of granular SPC in solution divided into three times a day. Once every 5 to 7 weeks, subjects were interviewed, given an additional drug supply, administered a kidney ultrasound and had spot urine samples collected for relevant biochemical analysis. From the recorded ultrasound images, rates of stone size reduction per year (ROSRPY) were calculated. The mean ROSRPY was 28.6+/-16.0% and 33.8+/-23.6% for G1 and G2, respectively. These two means were not significantly different. ROSRPY values of G1 and G2 were combined and divided into three levels: Level A (ROSRPY > mean + 0.5 SD), Level M (ROSRPY = mean +/- 0.5 SD) and Level B (ROSRPY < mean - 0.5 SD). Dissolution of stones was least in Level B which was related to higher excretions of Ca and uric acid in the urine. After treatment, 90% of the initial clinical symptoms (ie back pain, headaches and joint pain) were relieved. Fatigue and loss of appetite were observed in 26.3% of G2 subjects. Our study indicates that treatment of renal calculi with OG tea is an alternative means of management. Further investigation is needed to improve dissolution of stones with a low ROSRPY.
本研究旨在比较草药植物大花肾茶（OG）与药物柠檬酸钾钠（SPC）治疗肾结石的疗效。通过超声检查确定的48名农村结石患者被招募并随机分为两个治疗组（G1和G2）。在长达18个月的时间里，G1组的受试者每天饮用2杯OG茶，每杯茶由一个OG茶包制成（含2.5克干重），G2组的受试者每天分三次服用5 - 10克颗粒状SPC溶液。每5至7周对受试者进行一次访谈，给予额外的药物供应，进行肾脏超声检查，并采集即时尿样进行相关生化分析。根据记录的超声图像，计算每年结石尺寸减小率（ROSRPY）。G1组和G2组的平均ROSRPY分别为28.6±16.0%和33.8±23.6%。这两个平均值没有显著差异。将G1组和G2组的ROSRPY值合并并分为三个水平：A水平（ROSRPY>平均值+0.5标准差）、M水平（ROSRPY =平均值±0.5标准差）和B水平（ROSRPY<平均值-0.5标准差）。B水平的结石溶解最少，这与尿液中钙和尿酸的排泄量较高有关。治疗后，90%的初始临床症状（即背痛、头痛和关节痛）得到缓解。G2组26.3%的受试者出现疲劳和食欲不振。我们的研究表明，用OG茶治疗肾结石是一种可供选择的治疗方法。需要进一步研究以提高ROSRPY较低的结石的溶解率。
