Yoshimura Mamiko, Nakano Yoshio, Koga Toshihiko
Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, 3-1-1 Maidashi, Fukuoka, Higashi-ku, 812-8582, Japan.
Biochem Biophys Res Commun. 2002 Apr 12;292(4):964-8. doi: 10.1006/bbrc.2002.6747.
Methyl mercaptan is a major component responsible for oral malodor. This compound arises from the bacterial metabolism of methionine. Here we show that the growth of Porphyromonas gingivalis, a periodontal microorganism that produces large amounts of methyl mercaptan, was strongly inhibited by l-trifluoromethionine (TFM), a fluorinated derivative of methionine. In contrast, TFM had no effect on the growth of bacteria which do not produce methyl mercaptan. In addition, the survival rate of P. gingivalis-infected mice was remarkably increased by the co-injection of TFM. These results suggest that TFM is a promising antibacterial agent specific to the malodorous oral bacteria.
甲硫醇是导致口腔异味的主要成分。这种化合物源自蛋氨酸的细菌代谢。在此我们表明，牙龈卟啉单胞菌（一种产生大量甲硫醇的牙周微生物）的生长受到l-三氟甲硫氨酸（TFM，蛋氨酸的氟化衍生物）的强烈抑制。相比之下，TFM对不产生甲硫醇的细菌的生长没有影响。此外，同时注射TFM可显著提高感染牙龈卟啉单胞菌的小鼠的存活率。这些结果表明，TFM是一种有前景的针对产生异味的口腔细菌的特异性抗菌剂。
