Kuo Chin-Sung, Hwu Chii-Min, Lin Yueh-Hui, Huang Ya-Hsueh, Kao Wei-Yi, Weih Mei-Jy, Hsiao Li-Chuan, Kwok Ching Fai, Ho Low-Tone
Endocrinology and Metabolism Section, Department of Medicine, Taipei Veterans General Hospital, Taiwan, Republic of China.
J Clin Lab Anal. 2002;16(2):109-14. doi: 10.1002/jcla.10030.
We describe a new portable uric acid (UA) meter, called the UASure (Apex Biotechnology Corp., Hsinchu, Taiwan). The UASure is an electrochemical blood UA meter designed for fast monitoring of UA concentrations in one drop of capillary blood using an electrochemical test strip. We compared the UASure with the standard method, the Hitachi 7600 modular system (Hitachi, Tokyo, Japan), in 146 volunteers (average age 62.5 +/- 12.8 years). Of these, 65 were known hyperuricemic subjects, 17 of whom received medical therapy. The patients donated their capillary and venous blood samples in random order. Capillary blood and one drop of venous blood were tested immediately by the UASure. The venous blood in the test tube was sent to the central laboratory for serum UA measurement by the Hitachi 7600. The intra-assay coefficients of variation (CVs) of the UASure were 4.79%, 5.77%, and 3.08% at UA levels of 5.8, 7.1, and 13.5 mg/dl, respectively. The UA concentrations tested by the UASure correlated well with those by the Hitachi 7600 (r = 0.87 in venous sampling and r = 0.78 in capillary sampling, P < 0.001). The intraclass correlation was good for venous samples by the UASure (rI = 0.84, 95% CI 0.82-0.90), somewhat below the meaningful criterion for capillary samples by the UASure (rI = 0.77, 95% CI 0.69-0.83). UASure with venous sampling is interchangeable with the standard method for UA measurement.
我们描述了一种名为UASure（台湾新竹的Apex生物技术公司）的新型便携式尿酸（UA）测量仪。UASure是一种电化学血液尿酸测量仪，设计用于使用电化学测试条快速监测一滴毛细血管血中的尿酸浓度。我们在146名志愿者（平均年龄62.5±12.8岁）中，将UASure与标准方法日立7600模块化系统（日本东京日立公司）进行了比较。其中，65名是已知的高尿酸血症患者，其中17名接受了药物治疗。患者随机顺序捐献毛细血管血和静脉血样本。UASure立即对毛细血管血和一滴静脉血进行检测。试管中的静脉血被送到中央实验室，由日立7600测量血清尿酸。UASure在尿酸水平为5.8、7.1和13.5mg/dl时的批内变异系数（CVs）分别为4.79%、5.77%和3.08%。UASure检测的尿酸浓度与日立7600检测的浓度相关性良好（静脉采样时r = 0.87，毛细血管采样时r = 0.78，P < 0.001）。UASure对静脉样本的组内相关性良好（rI = 0.84，95%CI 0.82 - 0.90），略低于UASure对毛细血管样本有意义的标准（rI = 0.77，95%CI 0.69 - 0.83）。采用静脉采样的UASure与尿酸测量的标准方法可互换使用。
