Apgar J
J Nutr. 1975 Dec;105(12):1553-61. doi: 10.1093/jn/105.12.1553.
Relation of food consumption to stress at parturition in rats was investigated in three experiments. (1) Females receiving a low thiamin intake during gestation were compared with those receiving a low zinc intake and those receiving either a restricted or ad libitum food intake with adequate zinc. Litter size was reduced in the low thiamin group. Malformed offspring were noted in the other three groups. Little stress at parturition was evident in any of the groups. Serum progesterone concentrations on day 18 were elevated in all three experimental groups relative to ad libitum controls. Urinary hydroxyproline in females with low zinc intakes did not differ from that in ad libitum controls. (2) A 5% protein diet increased food intake only slightly in females with low zinc intake and resulted in death at the end of gestation. (3) Force feeding of pregnant females was unsuccessful, but results with females given the low zinc diet or restricted amounts of the diet plus zinc supported results obtained in the other two experiments. The possibility that stress at parturition was related to the ability of the females to make normal hemodynamic adjustments to pregnancy is discussed.
在三项实验中研究了大鼠分娩时食物消耗与应激之间的关系。（1）将妊娠期硫胺素摄入量低的雌性大鼠与锌摄入量低的雌性大鼠以及锌摄入充足但食物摄入量受限或自由采食的雌性大鼠进行比较。硫胺素摄入量低的组产仔数减少。其他三组中均发现有畸形后代。在任何一组中，分娩时的应激都不明显。相对于自由采食的对照组，所有三个实验组在第18天的血清孕酮浓度均升高。锌摄入量低的雌性大鼠的尿羟脯氨酸与自由采食对照组无差异。（2）5%蛋白质饮食仅使锌摄入量低的雌性大鼠的食物摄入量略有增加，并导致妊娠末期死亡。（3）对怀孕雌性大鼠进行强制喂食未成功，但给低锌饮食或限制饮食加锌的雌性大鼠的实验结果支持了其他两项实验的结果。讨论了分娩时的应激与雌性大鼠对妊娠进行正常血液动力学调节能力之间的关系。
