Stevens Beth, Fields R Douglas
Laboratory of Cellular and Synaptic Neurophysiology, National Institutes of Health, NICHD, Bethesda, Maryland 20895-4495, USA.
Neuroscientist. 2002 Apr;8(2):93-7. doi: 10.1177/107385840200800205.
Precise regulation of the glial cell cycle is essential during nervous system development and in response to injury, whereas disruption of cell cycle control is associated with malignant glial tumors and other nervous system diseases. The Ras signaling pathway plays a central role in regulating the mammalian cell cycle, and uncontrolled Ras signaling has been implicated in a wide range of human cancers, including malignant gliomas. Recent studies in glia have demonstrated that activation of Ras can either induce or inhibit proliferation through complex interactions among downstream signaling pathways impinging on cell cycle regulatory proteins. Studies in Schwann cells have begun to delineate the pathways by which Ras regulates the cell cycle in normal and pathological glia, and have identified promising targets for therapeutic intervention in the treatment of PNS and CNS malignant glial tumors.
在神经系统发育过程以及对损伤的反应中，神经胶质细胞周期的精确调控至关重要，而细胞周期控制的破坏与恶性神经胶质瘤和其他神经系统疾病相关。Ras信号通路在调节哺乳动物细胞周期中起核心作用，并且不受控制的Ras信号传导与包括恶性神经胶质瘤在内的多种人类癌症有关。最近在神经胶质细胞中的研究表明，Ras的激活可通过影响细胞周期调节蛋白的下游信号通路之间的复杂相互作用来诱导或抑制增殖。在雪旺细胞中的研究已开始阐明Ras在正常和病理性神经胶质细胞中调节细胞周期的途径，并已确定了在治疗周围神经系统和中枢神经系统恶性神经胶质瘤方面有前景的治疗干预靶点。
