Sanderson Maureen, Wang Jing, Davis Dorothy R, Lane Marcia J, Cornman Carol B, Fadden Mary K
Alzheimer's Disease Registry, Norman J. Arnold School of Public Health, University of South Carolina, Columbia, USA.
Am J Alzheimers Dis Other Demen. 2002 Mar-Apr;17(2):73-8. doi: 10.1177/153331750201700210.
The purpose of this study was to identify common co-morbid conditions associated with dementia subtypes and to evaluate the association of hypertension, diabetes mellitus, atrial fibrillation, congestive heart failure, and anemia with dementia subtypes relative to controls.
Hospital discharge data were used to identify 15,013 subjects from South Carolina with a diagnosis of dementia between 1998 and 1999. A control group of 15,013 persons without dementia was randomly sampled from hospital discharge records and matched to persons with dementia on the basis of age, race, and gender. Multiple hospitalizations for each patient were merged, and repeated diagnoses during separate hospitalizations were counted once.
After adjusting for age, race, and gender, persons with Alzheimer's disease and dementia associated with medical conditions were less likely to be diagnosed with hypertension, diabetes, congestive heart failure, and atrial fibrillation than were controls. Patients with multi-infarct dementia were also less likely to have congestive heart failure, but were more likely to have diabetes. Anemia was not associated with any dementia subtype.
There are distinct differences in comorbid conditions among dementia subtypes. Our research does not support previous studies that suggest a circulatory component to the development of Alzheimer's disease.
本研究旨在确定与痴呆亚型相关的常见共病情况，并评估高血压、糖尿病、心房颤动、充血性心力衰竭和贫血与痴呆亚型相对于对照组之间的关联。
利用医院出院数据从南卡罗来纳州确定了1998年至1999年间诊断为痴呆的15013名受试者。从医院出院记录中随机抽取15013名无痴呆的对照组人员，并根据年龄、种族和性别与痴呆患者进行匹配。合并每位患者的多次住院情况，单独住院期间的重复诊断只计算一次。
在对年龄、种族和性别进行调整后，与对照组相比，阿尔茨海默病患者和与医疗状况相关的痴呆患者被诊断为高血压、糖尿病、充血性心力衰竭和心房颤动的可能性较小。多发性梗死性痴呆患者患充血性心力衰竭的可能性也较小，但患糖尿病的可能性较大。贫血与任何痴呆亚型均无关联。
痴呆亚型之间的共病情况存在明显差异。我们的研究不支持先前表明阿尔茨海默病发展存在循环成分的研究。
