Landin K, Blennow K, Wallin A, Gottfries C G
Department of Medicine II, Sahlgrenska Hospital, Göteborg, Sweden.
J Intern Med. 1993 Apr;233(4):357-63. doi: 10.1111/j.1365-2796.1993.tb00684.x.
To test possible differences between patients with Alzheimer's disease (AD) and patients with other forms of dementia and the healthy population concerning body composition, blood pressure, metabolic data and leukoaraiosis (LA).
Retrospective study on data collected according to a predefined protocol.
A geriatric, neuropsychiatric diagnostic unit.
Seventy-one consecutive patients with dementia.
Body mass index, blood pressure, metabolism and LA in AD compared to other dementia forms.
Mean blood pressure and fasting blood glucose levels were lower in patients with AD, 94 +/- 12 mmHg and 4.3 +/- 0.5 mmol l-1, compared to patients with unspecified dementia (NUD), 100 +/- 10 mmHg and 5.5 +/- 2.5 mmol l-1 (P < 0.05) and vascular dementia (VAD), 114 +/- 12 mmHg and 5.6 +/- 1.6 mmol l-1 (P < 0.001) and the age-matched healthy population. Body mass index, serum cholesterol and cortisol were similar in all groups of dementia patients whereas triglycerides were highest in the VAD group. No cases of diabetes or treatment for hypertension were found in the AD group while the prevalence was 21% and 36% for diabetes in the NUD and VAD groups and 8% in the population from the same region. There were 16% with antihypertensive treatment in dementia NUD, 50% in VAD, and 30% in the general population. Treated or newly detected hypothyreosis was present in 11% of the AD patients, none in the other dementia groups and 2% in the general population. Smoking was least common in AD. Degree of LA correlated with blood pressure and blood glucose levels.
AD was clearly different to other dementia patients. They had lower blood pressure, blood glucose and higher prevalence of hypothyreosis than the healthy, age-matched population. These findings may indicate that AD could be a hypometabolic disorder.
检测阿尔茨海默病（AD）患者、其他形式痴呆患者以及健康人群在身体成分、血压、代谢数据和脑白质疏松（LA）方面可能存在的差异。
根据预定义方案对收集的数据进行回顾性研究。
一个老年神经精神诊断单元。
71例连续的痴呆患者。
将AD患者与其他痴呆形式患者的体重指数、血压、代谢和LA进行比较。
与未明确类型痴呆（NUD）患者（收缩压100±10 mmHg，舒张压5.5±2.5 mmol/L）、血管性痴呆（VAD）患者（收缩压114±12 mmHg，舒张压5.6±1.6 mmol/L）以及年龄匹配的健康人群相比，AD患者的平均血压和空腹血糖水平较低，分别为94±12 mmHg和4.3±0.5 mmol/L（P<0.05）以及（P<0.001）。所有痴呆患者组的体重指数、血清胆固醇和皮质醇相似，而甘油三酯在VAD组中最高。AD组未发现糖尿病或高血压治疗病例，而NUD组和VAD组的糖尿病患病率分别为21%和36%，同一地区人群的患病率为8%。痴呆NUD组有16%接受抗高血压治疗，VAD组为50%，普通人群为30%。11%的AD患者存在经治疗或新检测出的甲状腺功能减退，其他痴呆组均无，普通人群为2%。AD患者吸烟最少见。LA程度与血压和血糖水平相关。
AD与其他痴呆患者明显不同。与年龄匹配的健康人群相比，他们的血压、血糖较低，甲状腺功能减退患病率较高。这些发现可能表明AD可能是一种低代谢性疾病。
