Cheng Qi, Wang De-Sheng, Jiang Guo-Xin, Han Hui, Zhang Yan, Wang Wen-Zhi, Fredrikson Sten
Division of Neurology, Huddinge University Hospital, Sweden.
J Neurol. 2002 Jan;249(1):25-32. doi: 10.1007/pl00007844.
We describe the age-and sex-specific incidence of Guillain-Barré syndrome (GBS) in Harbin, China, based on the information from a prospective survey among a well-defined large population during one year. A network of physicians reported incident patients with a GBS diagnosis from a general population of 5.4 million inhabitants in Harbin, China, during the period from 1 October 1997 to 30 September 1998. Each reported patient was examined by senior neurologists and the GBS diagnosis was validated according to standard diagnostic criteria. All GBS patients were followed-up for six months after onset. Admission registers at all hospitals in Harbin were also checked afterwards for screening patients with a GBS diagnosis who might have been missed. During the study period, 79 patients with a GBS diagnosis were reported. After validation, the GBS diagnosis was confirmed in 70 patients. Another GBS patient was found through the screening of admission registers at hospitals. Among them, 36 GBS patients were residents in Harbin and the other 35 patients were from geographical areas out of Harbin. The GBS incidence, age-adjusted to the European standard population, was 0.66 (95% CI 0.46-0.91) per 100,000 person-years, with a male to female ratio of 1.4. The highest GBS incidence was found in the youngest age-group and the incidence among the elderly was remarkably lower than those reported from other populations in Western countries. Possible explanations for the distinct pattern of age-specific incidence of GBS are discussed. Further studies are needed.
我们根据对中国哈尔滨一个明确界定的大群体进行的为期一年的前瞻性调查所获得的信息，描述了吉兰 - 巴雷综合征（GBS）的年龄和性别特异性发病率。在1997年10月1日至1998年9月30日期间，一个医生网络报告了来自中国哈尔滨540万居民总人口中确诊为GBS的发病患者。每位报告的患者都由资深神经科医生进行检查，并根据标准诊断标准对GBS诊断进行验证。所有GBS患者在发病后随访6个月。之后还检查了哈尔滨所有医院的入院登记册，以筛查可能漏诊的GBS诊断患者。在研究期间，报告了79例诊断为GBS的患者。经过验证，70例患者的GBS诊断得到确认。通过筛查医院入院登记册又发现了1例GBS患者。其中，36例GBS患者是哈尔滨居民，另外35例患者来自哈尔滨以外的地区。根据欧洲标准人群进行年龄调整后的GBS发病率为每10万人年0.66（95%CI 0.46 - 0.91），男女比例为1.4。GBS发病率在最年轻年龄组中最高，老年人中的发病率明显低于西方国家其他人群报告的发病率。文中讨论了GBS年龄特异性发病率独特模式的可能解释。还需要进一步研究。
