1985年至2020年间全球格林-巴利综合征的发病率：一项系统综述。
Incidence of Guillain-Barré syndrome in the world between 1985 and 2020: A systematic review.
作者信息
Wachira Virginia Kagure, Farinasso Cecília Menezes, Silva Roberta Borges, Peixoto Henry Maia, de Oliveira Maria Regina Fernandes
机构信息
Núcleo de Medicina Tropical, Faculdade de Medicina, Universidade de Brasília, Brasília, Brazil.
Hospital Alemão Oswaldo Cruz, São Paulo, Brazil.
出版信息
Glob Epidemiol. 2023 Jan 11;5:100098. doi: 10.1016/j.gloepi.2023.100098. eCollection 2023 Dec.
INTRODUCTION
Guillain-Barré syndrome (GBS) is an acute inflammatory demyelinating polyradiculoneuropathy that affects the peripheral nervous system. The study aimed to describe the incidence of GBS in the world up to the year 2020.
METHODS
A systematic review was conducted. Searches were done in four databases, PUBMED, EMBASE, EBSCO and , and in grey literature and manual search in the reference lists of eligible studies.
RESULTS
A total of 72 studies were included. The incidence of GBS among the cohort studies varied from 0.30 to 6.08 cases per 100.000 habitants and 0.42 to 6.58 cases per 100.000 person-years. Among the self-controlled studies, the risk incidence ranged from 0.072 to 1 case per 100.000 habitants and 1.73 to 4.30 cases per 100.000 person-years.
CONCLUSIONS
The reported incidence of GBS in the world among the studies included in the review is slightly higher than that reported in previous studies. The highest incidence rates were associated with public health events of international concern.
引言
吉兰 - 巴雷综合征（GBS）是一种影响周围神经系统的急性炎症性脱髓鞘性多发性神经根神经病。该研究旨在描述截至2020年全球GBS的发病率。
方法
进行了一项系统评价。在四个数据库（PUBMED、EMBASE、EBSCO和[此处原文缺失一个数据库名称]）以及灰色文献中进行检索，并在符合条件研究的参考文献列表中进行手动检索。
结果
共纳入72项研究。队列研究中GBS的发病率为每10万居民0.30至6.08例，每10万人年0.42至6.58例。在自我对照研究中，风险发病率为每10万居民0.072至1例，每10万人年1.73至4.30例。
结论
该综述纳入的研究中报告的全球GBS发病率略高于先前研究报告的发病率。最高发病率与国际关注的公共卫生事件相关。
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