Wu Taishun, Li Songlin, Chen Shupei, Wu Likang, Xiao Jinhui, Nie Shaofa, Chen Wei, Zhu Guibao
Department of Science and Teaching, The Hygiene and Anti-epidemic Station of Baoan District, Shenzhen City, Shenzhen 518101, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2002 Jan;36(1):19-21.
To investigate the risk factors for congenital external malformation.
A 1:2 matched case-control study was conducted with 52 cases of congenital external malformation during perinantal period collected from surveillance in Baoan District of Shenzhen City from January to June in 2000.
Simple and multiple conditional logistic regression analysis showed that the major risk factors for congenital external malformations during perinatal period were preterm labor (beta(k) = 1.4171, s(theta, beta(kappa)) = 0.4601, OR = 4.115), adverse mental stimulus (beta(kappa) = 2.1870, s(theta beta(kappa)) = 0.7873, OR = 8.909), taking medicine (beta(k) = 1.9178, s(theta beta(kappa)) = 0.8072, OR = 6.808) and exposure to hazardous chemicals during early pregnancy (beta(k) = 0.9602, s(theta beta(kappa)) = 0.4262, OR = 2.612).
Congenital external malformation during perinatal period was caused by multiple risk factors and results of the study showed that environmental and mental factors were in obvious connection with its occurrence.
探讨先天性外部畸形的危险因素。
采用1:2配对病例对照研究，收集了2000年1月至6月深圳市宝安区监测的52例围产期先天性外部畸形病例。
单因素和多因素条件logistic回归分析显示，围产期先天性外部畸形的主要危险因素为早产（β(k)=1.4171，s(θ,β(kappa))=0.4601，OR=4.115）、不良精神刺激（β(kappa)=2.1870，s(θβ(kappa))=0.7873，OR=8.909）、服药（β(k)=1.9178，s(θβ(kappa))=0.8072，OR=6.808）以及孕早期接触有害化学物质（β(k)=0.9602，s(θβ(kappa))=0.4262，OR=2.612）。
围产期先天性外部畸形由多种危险因素所致，研究结果表明环境和心理因素与其发生明显相关。
