[一项围产期先天性外部畸形的1:2配对病例对照研究]

[A 1:2 matched case-control study on congenital external malformation during perinatal period].

作者信息

Wu Taishun, Li Songlin, Chen Shupei, Wu Likang, Xiao Jinhui, Nie Shaofa, Chen Wei, Zhu Guibao

机构信息

Department of Science and Teaching, The Hygiene and Anti-epidemic Station of Baoan District, Shenzhen City, Shenzhen 518101, China.

出版信息

Zhonghua Yu Fang Yi Xue Za Zhi. 2002 Jan;36(1):19-21.

PMID:11955342

Abstract

OBJECTIVE

To investigate the risk factors for congenital external malformation.

METHODS

A 1:2 matched case-control study was conducted with 52 cases of congenital external malformation during perinantal period collected from surveillance in Baoan District of Shenzhen City from January to June in 2000.

RESULTS

Simple and multiple conditional logistic regression analysis showed that the major risk factors for congenital external malformations during perinatal period were preterm labor (beta(k) = 1.4171, s(theta, beta(kappa)) = 0.4601, OR = 4.115), adverse mental stimulus (beta(kappa) = 2.1870, s(theta beta(kappa)) = 0.7873, OR = 8.909), taking medicine (beta(k) = 1.9178, s(theta beta(kappa)) = 0.8072, OR = 6.808) and exposure to hazardous chemicals during early pregnancy (beta(k) = 0.9602, s(theta beta(kappa)) = 0.4262, OR = 2.612).

CONCLUSIONS

Congenital external malformation during perinatal period was caused by multiple risk factors and results of the study showed that environmental and mental factors were in obvious connection with its occurrence.

摘要

目的

探讨先天性外部畸形的危险因素。

方法

采用1:2配对病例对照研究，收集了2000年1月至6月深圳市宝安区监测的52例围产期先天性外部畸形病例。

结果

单因素和多因素条件logistic回归分析显示，围产期先天性外部畸形的主要危险因素为早产（β(k)=1.4171，s(θ,β(kappa))=0.4601，OR=4.115）、不良精神刺激（β(kappa)=2.1870，s(θβ(kappa))=0.7873，OR=8.909）、服药（β(k)=1.9178，s(θβ(kappa))=0.8072，OR=6.808）以及孕早期接触有害化学物质（β(k)=0.9602，s(θβ(kappa))=0.4262，OR=2.612）。