Qiu Xiao-qiang, Zeng Xiao-yun, Qin Dan-dan, Zhong Xi-hong, Lin Mo-ju, Zhang Hong-li, Huang Dong
Department of Epidemiology, Public Health College of Guangxi Medical University, Nanning 530021, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2003 Jun;24(6):512-5.
To investigate the possible risk factors of congenital malformations in cities of Guangxi.
A case-control study was carried out on 281 cases of congenital malformations and 730 controls. Analysis of simple factor and multiple factors unconditional logistic regression were done.
The analysis of simple factor and multiple factors showed that main risk factors of congenital malformations as multiple pregnancies (OR = 2.6), pregnancy complications (OR = 3.2), exposure to chemical substances before or during pregnancy (OR = 3.0), taking sedatives (OR = 10.2), hormone drug (OR = 9.4) or Chinese herbal medicines (OR = 2.5) during the early stage of pregnancy, mothers' blood type as AB (OR = 3.5) or A (OR = 2.2), mothers' emotion being nervous and melancholy (OR = 2.6), mothers' occupation being workers (OR = 3.8) or peasants (OR = 3.0), fathers' exposure to noise (OR = 5.7) or suffering from chronic diseases (OR = 2.8).
Some risk factors were identified as having important effect on perinatal congenital malformations, including taking sedatives, hormone drug or Chinese herbal medicines during the early stage of pregnancy, mothers' emotion being nervous and melancholy, multiple pregnancies, pregnancy complications, exposure to chemical substances before or during pregnancies, mothers' blood type as AB or A, mothers' occupation being workers or peasants, fathers' exposure to noise or suffering from chronic diseases.
探讨广西城市先天性畸形的可能危险因素。
对281例先天性畸形病例和730例对照进行病例对照研究。进行单因素和多因素无条件逻辑回归分析。
单因素和多因素分析显示，先天性畸形的主要危险因素有多胎妊娠（OR = 2.6）、妊娠并发症（OR = 3.2）、孕期前或孕期接触化学物质（OR = 3.0）、孕期早期服用镇静剂（OR = 10.2）、激素药物（OR = 9.4）或中草药（OR = 2.5）、母亲血型为AB型（OR = 3.5）或A型（OR = 2.2）、母亲情绪紧张和忧郁（OR = 2.6）、母亲职业为工人（OR = 3.8）或农民（OR = 3.0）、父亲接触噪声（OR = 5.7）或患有慢性病（OR = 2.8）。
确定了一些对围产期先天性畸形有重要影响的危险因素，包括孕期早期服用镇静剂、激素药物或中草药、母亲情绪紧张和忧郁、多胎妊娠、妊娠并发症、孕期前或孕期接触化学物质、母亲血型为AB型或A型、母亲职业为工人或农民、父亲接触噪声或患有慢性病。
