French Audrey L, Cohen Mardge H, Gange Stephen J, Burger Harold, Gao Wei, Semba Richard D, Meyer William A, Robison Esther, Anastos Kathryn
Division of Infectious Diseases, Durand 115, Cook County Hospital, 1835 West Harrison Street, Chicago, IL 60612, USA.
Lancet. 2002 Apr 6;359(9313):1210-2. doi: 10.1016/S0140-6736(02)08226-0.
The relation between vitamin A (retinol) deficiency and perinatal transmission of HIV-1, if it exists, might be mediated through an increased viral load in the mother's genital tract. To ascertain whether or not such an association is present, we measured the serum concentration of retinol with high performance liquid chromatography, and correlated the results with concurrent quantified HIV-1 RNA concentrations in cervicovaginal lavage fluid in 301 women infected with the virus. We noted no association between retinol status and genital HIV-1 load. Our findings lend support to those of studies that reported no association between retinol deficiency and perinatal HIV-1 transmission.
维生素A（视黄醇）缺乏与HIV-1围产期传播之间的关系（如果存在的话），可能是通过母亲生殖道中病毒载量的增加来介导的。为了确定是否存在这种关联，我们用高效液相色谱法测量了血清视黄醇浓度，并将结果与301名感染该病毒的女性宫颈阴道灌洗液中同时测定的HIV-1 RNA浓度进行了关联分析。我们发现视黄醇状态与生殖道HIV-1载量之间没有关联。我们的研究结果支持了那些报道视黄醇缺乏与围产期HIV-1传播之间没有关联的研究。
