一例伴有血清肥大细胞类胰蛋白酶升高的羊水栓塞致死病例。
A fatal case of amniotic fluid embolism with elevation of serum mast cell tryptase.
作者信息
Nishio Hajime, Matsui Kiyoshi, Miyazaki Tokiko, Tamura Akiyoshi, Iwata Misa, Suzuki Koichi
机构信息
Department of Legal Medicine, Osaka Medical College, 569-8686, Takatsuki, Japan.
出版信息
Forensic Sci Int. 2002 Mar 28;126(1):53-6. doi: 10.1016/s0379-0738(02)00034-8.
A case of a 40-year-old female who died of amniotic fluid embolism is presented. This case showed typical histological findings of this syndrome. Postmortem serum of this case showed an elevated tryptase level (67.2ng/ml, normal levels <10ng/ml). Tryptase is a neutral protease of mast cells, and an important indicator of mast cell activation and degranulation. Thus, mast cell activation, a central feature of anaphylaxis, may have been involved in the pathogenetic mechanism of this case.
本文报告一例40岁死于羊水栓塞的女性病例。该病例显示了该综合征典型的组织学表现。该病例的尸检血清显示类胰蛋白酶水平升高（67.2ng/ml，正常水平<10ng/ml）。类胰蛋白酶是肥大细胞的一种中性蛋白酶，是肥大细胞活化和脱颗粒的重要指标。因此，过敏反应的核心特征——肥大细胞活化，可能参与了该病例的发病机制。
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