• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Embryonic platelet-activating factor: temporal expression of the ligand and receptor.胚胎血小板激活因子：配体与受体的时间表达
J Assist Reprod Genet. 2002 Feb;19(2):72-8. doi: 10.1023/a:1014443630722.
2
Evidence for the presence of the platelet-activating factor receptor in the CFW mouse preimplantation two-cell-stage embryo.CFW小鼠植入前二细胞期胚胎中存在血小板活化因子受体的证据。
Biol Reprod. 1997 Sep;57(3):575-9. doi: 10.1095/biolreprod57.3.575.
3
Role of messenger RNA expression of platelet activating factor and its receptor in porcine in vitro-fertilized and cloned embryo development.血小板活化因子及其受体的信使核糖核酸表达在猪体外受精和克隆胚胎发育中的作用
Biol Reprod. 2004 Sep;71(3):919-25. doi: 10.1095/biolreprod.103.026138. Epub 2004 May 19.
4
Ontogeny of expression of a receptor for platelet-activating factor in mouse preimplantation embryos and the effects of fertilization and culture in vitro on its expression.小鼠植入前胚胎中血小板活化因子受体表达的个体发生以及体外受精和培养对其表达的影响。
Biol Reprod. 1999 Mar;60(3):674-82. doi: 10.1095/biolreprod60.3.674.
5
Influence of the preimplantation embryo development (Ped) gene on embryonic platelet-activating factor (PAF) levels.着床前胚胎发育（Ped）基因对胚胎血小板活化因子（PAF）水平的影响。
J Assist Reprod Genet. 2006 Jun;23(6):269-73. doi: 10.1007/s10815-006-9039-z. Epub 2006 Jun 24.
6
Evidence for the requirement of autocrine growth factors for development of mouse preimplantation embryos in vitro.自分泌生长因子对小鼠体外植入前胚胎发育的必要性的证据。
Biol Reprod. 1997 Jan;56(1):229-37. doi: 10.1095/biolreprod56.1.229.
7
PAF receptor and PAF acetylhydrolase expression in the endosalpinx of the human Fallopian tube: possible role of embryo-derived PAF in the control of embryo transport to the uterus.血小板活化因子受体和血小板活化因子乙酰水解酶在人输卵管内膜中的表达：胚胎源性血小板活化因子在控制胚胎向子宫转运中的可能作用。
Hum Reprod. 2001 Aug;16(8):1583-7. doi: 10.1093/humrep/16.8.1583.
8
Metabolic and developmental responses of preimplantation embryos to platelet activating factor (PAF).植入前胚胎对血小板活化因子（PAF）的代谢和发育反应。
Reprod Fertil Dev. 1992;4(4):387-98. doi: 10.1071/rd9920387.
9
Platelet-activating factor increases intracellular calcium levels in preimplantation stage embryos.血小板活化因子可提高着床前阶段胚胎的细胞内钙水平。
Early Pregnancy (Cherry Hill). 2000 Jan;4(1):30-8.
10
Exposure of preimplantation embryos to platelet-activating factor increases birth rate.植入前胚胎暴露于血小板活化因子可提高出生率。
J Assist Reprod Genet. 2004 Aug;21(8):297-300. doi: 10.1023/b:jarg.0000043703.73207.25.

引用本文的文献

1
Roles of insulin-like growth factor II in regulating female reproductive physiology.胰岛素样生长因子 II 在调节女性生殖生理中的作用。
Sci China Life Sci. 2020 Jun;63(6):849-865. doi: 10.1007/s11427-019-1646-y. Epub 2020 Apr 10.
2
Exposure of preimplantation embryos to platelet-activating factor increases birth rate.植入前胚胎暴露于血小板活化因子可提高出生率。
J Assist Reprod Genet. 2004 Aug;21(8):297-300. doi: 10.1023/b:jarg.0000043703.73207.25.

本文引用的文献

1
Exogenous platelet-activating factor stimulates cell proliferation in mouse pre-implantation embryos prior to the fourth cell cycle and shows isoform-specific stimulatory effects.外源性血小板活化因子在小鼠植入前胚胎的第四个细胞周期之前刺激细胞增殖，并表现出亚型特异性刺激作用。
Zygote. 2001 Aug;9(3):261-8. doi: 10.1017/s0967199401001289.
2
Ontogeny of expression of a receptor for platelet-activating factor in mouse preimplantation embryos and the effects of fertilization and culture in vitro on its expression.小鼠植入前胚胎中血小板活化因子受体表达的个体发生以及体外受精和培养对其表达的影响。
Biol Reprod. 1999 Mar;60(3):674-82. doi: 10.1095/biolreprod60.3.674.
3
Autocrine mediators are required to act on the embryo by the 2-cell stage to promote normal development and survival of mouse preimplantation embryos in vitro.自分泌介质需要在2细胞阶段作用于胚胎，以促进小鼠植入前胚胎在体外的正常发育和存活。
Biol Reprod. 1998 May;58(5):1303-9. doi: 10.1095/biolreprod58.5.1303.
4
Agonist-induced sequestration, recycling, and resensitization of platelet-activating factor receptor. Role of cytoplasmic tail phosphorylation in each process.激动剂诱导的血小板活化因子受体的隔离、再循环和再敏化。细胞质尾磷酸化在每个过程中的作用。
J Biol Chem. 1998 Apr 17;273(16):9878-85. doi: 10.1074/jbc.273.16.9878.
5
The effect of short- vs. long-term platelet-activating factor exposure on mouse preimplantation embryo development.短期与长期暴露于血小板活化因子对小鼠植入前胚胎发育的影响。
Early Pregnancy. 1995 Sep;1(3):196-200.
6
Evidence for the presence of the platelet-activating factor receptor in the CFW mouse preimplantation two-cell-stage embryo.CFW小鼠植入前二细胞期胚胎中存在血小板活化因子受体的证据。
Biol Reprod. 1997 Sep;57(3):575-9. doi: 10.1095/biolreprod57.3.575.
7
Effect of platelet-activating factor (PAF) on preimplantation mouse B6D2F1/J embryo formation.血小板活化因子（PAF）对植入前小鼠B6D2F1/J胚胎形成的影响。
Am J Reprod Immunol. 1996 Mar;35(3):272-6. doi: 10.1111/j.1600-0897.1996.tb00044.x.
8
Stimulation of development in vitro by platelet-activating factor receptor ligands released by mouse preimplantation embryos.小鼠植入前胚胎释放的血小板活化因子受体配体对体外发育的刺激作用。
J Reprod Fertil. 1996 Sep;108(1):47-53. doi: 10.1530/jrf.0.1080047.
9
A murine platelet-activating factor receptor gene: cloning, chromosomal localization and up-regulation of expression by lipopolysaccharide in peritoneal resident macrophages.一种小鼠血小板活化因子受体基因：克隆、染色体定位及脂多糖对腹膜常驻巨噬细胞中表达的上调作用
Biochem J. 1996 Mar 1;314 ( Pt 2)(Pt 2):671-8. doi: 10.1042/bj3140671.
10
Stage-specific expression of cytokine and receptor messenger ribonucleic acids in human preimplantation embryos.细胞因子和受体信使核糖核酸在人类植入前胚胎中的阶段特异性表达。
Biol Reprod. 1995 Oct;53(4):974-81. doi: 10.1095/biolreprod53.4.974.

胚胎血小板激活因子：配体与受体的时间表达

Embryonic platelet-activating factor: temporal expression of the ligand and receptor.

作者信息

Roudebush William E, Purnell Elissa T, Stoddart Neil R, Fleming Steven D

机构信息

Reproductive Biology Associates, Atlanta, Georgia 30342, USA.

出版信息

J Assist Reprod Genet. 2002 Feb;19(2):72-8. doi: 10.1023/a:1014443630722.

DOI:10.1023/a:1014443630722
PMID:11958508
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3468223/
Abstract

PURPOSE

Preimplantation embryos synthesize platelet-activating factor (PAF) and this embryo-derived PAF is required for development. PAF's signal transduction is receptor-mediated and PAF-receptor mRNA is present in early embryos. The study objective was to determine the relationship between PAF production and PAF-receptor mRNA expression levels in mouse preimplantation embryos.

METHODS

Embryo-derived PAF levels were determined by radioimmunoassay. Embryonic PAF-receptor mRNA levels were determined by semiquantitated reverse transcription-polymerase chain reaction.

RESULTS

Embryonic-PAF increased as time progressed at a relatively constant rate (1.4-1.9 x) except between the eight- and morula-cell stages where levels increased sevenfold. Embryonic PAF-receptor expression was highest at the two-cell stage and decreased steadily until the morula stage before increasing again. Regression analysis of embryo-derived PAF on PAF-receptor expression does not demonstrate a significant relationship.

CONCLUSIONS

PAF-receptor expression (mRNA) levels decrease, while embryo-derived PAF levels decrease, as the preimplantation embryo develops. Embryonic-PAF and PAF-receptor mRNA expression do not appear related. Therefore, embryonic-PAF does not appear to regulate expression of its own receptor in vitro. The data provide a clue to the complicated cell signaling system involving PAF production and receptor expression that may help our understanding of developmental events.

摘要

目的

植入前胚胎可合成血小板活化因子（PAF），且胚胎来源的PAF是胚胎发育所必需的。PAF的信号转导是由受体介导的，并且PAF受体mRNA存在于早期胚胎中。本研究的目的是确定小鼠植入前胚胎中PAF产生与PAF受体mRNA表达水平之间的关系。

方法

通过放射免疫测定法测定胚胎来源的PAF水平。通过半定量逆转录-聚合酶链反应测定胚胎PAF受体mRNA水平。

结果

胚胎PAF随着时间的推移以相对恒定的速率增加（1.4 - 1.9倍），但在八细胞期和桑葚胚期之间水平增加了七倍。胚胎PAF受体表达在二细胞期最高，并持续下降直至桑葚胚期，然后再次上升。对胚胎来源的PAF与PAF受体表达进行回归分析未显示出显著关系。

结论

随着植入前胚胎的发育，PAF受体表达（mRNA）水平下降，而胚胎来源的PAF水平也下降。胚胎PAF和PAF受体mRNA表达似乎没有关联。因此，胚胎PAF在体外似乎不调节其自身受体的表达。这些数据为涉及PAF产生和受体表达的复杂细胞信号系统提供了线索，这可能有助于我们理解发育事件。