一种小鼠血小板活化因子受体基因：克隆、染色体定位及脂多糖对腹膜常驻巨噬细胞中表达的上调作用
A murine platelet-activating factor receptor gene: cloning, chromosomal localization and up-regulation of expression by lipopolysaccharide in peritoneal resident macrophages.
作者信息
Ishii S, Matsuda Y, Nakamura M, Waga I, Kume K, Izumi T, Shimizu T
机构信息
Department of Biochemistry, Faculty of Medicine, The University of Tokyo, Japan.
出版信息
Biochem J. 1996 Mar 1;314 ( Pt 2)(Pt 2):671-8. doi: 10.1042/bj3140671.
Abstract
A murine gene encoding a platelet-activating factor receptor (PAFR) was cloned. The gene was mapped to a region of the D2.2 band of chromosome 4 both by fluorescence in situ hybridization and by molecular linkage analysis. Northern blot analysis showed a high expression of the PAFR message in peritoneal macrophages. When C3H/HeN macrophages were treated with bacterial lipopolysaccharide (LPS) or synthetic lipid A, the PAFR gene expression was induced. Bacterial LPS, but not lipid A, induced the level of PAFR mRNA in LPS unresponsive C3H/HeJ macrophages. These induction patterns were parallel to those of tumor necrosis factor-alpha mRNA. Thus the PAFR in macrophages is important in LPS-induced pathologies.
摘要
克隆了一个编码血小板活化因子受体（PAFR）的小鼠基因。通过荧光原位杂交和分子连锁分析，该基因被定位到4号染色体D2.2带的一个区域。Northern印迹分析显示PAFR信息在腹膜巨噬细胞中高表达。当用细菌脂多糖（LPS）或合成脂质A处理C3H/HeN巨噬细胞时，PAFR基因表达被诱导。细菌LPS而非脂质A可诱导LPS无反应性C3H/HeJ巨噬细胞中PAFR mRNA的水平。这些诱导模式与肿瘤坏死因子-α mRNA的诱导模式平行。因此，巨噬细胞中的PAFR在LPS诱导的病理过程中很重要。
相似文献
1
A murine platelet-activating factor receptor gene: cloning, chromosomal localization and up-regulation of expression by lipopolysaccharide in peritoneal resident macrophages.一种小鼠血小板活化因子受体基因：克隆、染色体定位及脂多糖对腹膜常驻巨噬细胞中表达的上调作用
Biochem J. 1996 Mar 1;314 ( Pt 2)(Pt 2):671-8. doi: 10.1042/bj3140671.
2
Cloning and characterization of a murine platelet-activating factor receptor gene.小鼠血小板活化因子受体基因的克隆与特性分析
Adv Exp Med Biol. 1997;407:347-55. doi: 10.1007/978-1-4899-1813-0_52.
3
Expression of platelet-activating factor receptor in the hamster oviduct: localization to the endosalpinx.血小板活化因子受体在仓鼠输卵管中的表达：定位于输卵管内膜。
J Reprod Fertil. 1997 Mar;109(2):349-54. doi: 10.1530/jrf.0.1090349.
4
Two distinct signal transduction pathways for the activation of guinea-pig macrophages and neutrophils by endotoxin.内毒素激活豚鼠巨噬细胞和中性粒细胞的两条不同信号转导途径。
Biochem Biophys Res Commun. 1993 Dec 15;197(2):465-72. doi: 10.1006/bbrc.1993.2502.
5
6
Chromosomal location, structure, and temporal expression of the platelet-activating factor receptor (PAFr) gene in porcine endometrium and embryos relative to estrogen receptor alpha gene expression.猪子宫内膜和胚胎中血小板活化因子受体（PAFr）基因相对于雌激素受体α基因表达的染色体定位、结构及时间表达情况。
Mol Reprod Dev. 2003 Jan;64(1):4-12. doi: 10.1002/mrd.10217.
7
In situ expression of platelet-activating factor (PAF)-receptor gene in rat skin and effects of PAF on proliferation and differentiation of cultured human keratinocytes.血小板活化因子（PAF）受体基因在大鼠皮肤中的原位表达及PAF对培养的人角质形成细胞增殖和分化的影响。
J Invest Dermatol. 1998 Jun;110(6):889-93. doi: 10.1046/j.1523-1747.1998.00202.x.
8
PAFR activation of NF-κB p65 or p105 precursor dictates pro- and anti-inflammatory responses during TLR activation in murine macrophages.PAFR 激活 NF-κB p65 或 p105 前体决定 TLR 激活时小鼠巨噬细胞中的促炎和抗炎反应。
Sci Rep. 2016 Aug 24;6:32092. doi: 10.1038/srep32092.
9
Endotoxin-induced chemokine expression in murine peritoneal mesothelial cells: the role of toll-like receptor 4.内毒素诱导小鼠腹膜间皮细胞趋化因子表达：Toll样受体4的作用
J Am Soc Nephrol. 2004 May;15(5):1289-99.
10
The pig platelet-activating factor receptor gene is expressed at the mRNA level in different tissues and is mapped to chromosome 6.猪血小板激活因子受体基因在不同组织中以mRNA水平表达，并且被定位到6号染色体上。
Anim Reprod Sci. 2002 Apr 15;70(3-4):277-82. doi: 10.1016/s0378-4320(02)00019-2.
引用本文的文献
1
Integrated cellular 4D-TIMS lipidomics and transcriptomics for characterization of anti-inflammatory and anti-atherosclerotic phenotype of MyD88-KO macrophages.整合细胞4D-TIMS脂质组学和转录组学以表征MyD88基因敲除巨噬细胞的抗炎和抗动脉粥样硬化表型
Front Cell Dev Biol. 2024 Aug 23;12:1450971. doi: 10.3389/fcell.2024.1450971. eCollection 2024.
2
Exposure of preimplantation embryos to platelet-activating factor increases birth rate.植入前胚胎暴露于血小板活化因子可提高出生率。
J Assist Reprod Genet. 2004 Aug;21(8):297-300. doi: 10.1023/b:jarg.0000043703.73207.25.
3
Embryonic platelet-activating factor: temporal expression of the ligand and receptor.胚胎血小板激活因子：配体与受体的时间表达
J Assist Reprod Genet. 2002 Feb;19(2):72-8. doi: 10.1023/a:1014443630722.
4
Platelet-activating factor mediates acid-induced lung injury in genetically engineered mice.血小板活化因子介导基因工程小鼠的酸诱导性肺损伤。
J Clin Invest. 1999 Oct;104(8):1071-6. doi: 10.1172/JCI7727.
5
Platelet-activating factor receptor mRNA is localized in eosinophils and epithelial cells in rat small intestine: regulation by dexamethasone and gut flora.血小板活化因子受体mRNA在大鼠小肠的嗜酸性粒细胞和上皮细胞中定位：受地塞米松和肠道菌群调控。
Immunology. 1999 Jul;97(3):447-54. doi: 10.1046/j.1365-2567.1999.00784.x.
6
Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor.
J Exp Med. 1998 Jun 1;187(11):1779-88. doi: 10.1084/jem.187.11.1779.
7
Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor.过表达血小板活化因子受体的转基因小鼠的支气管高反应性、内毒素致死率增加及黑素细胞肿瘤发生
EMBO J. 1997 Jan 2;16(1):133-42. doi: 10.1093/emboj/16.1.133.
8
Predominant expression of platelet-activating factor receptor in the rat brain microglia.血小板活化因子受体在大鼠脑小胶质细胞中的主要表达
J Neurosci. 1996 Jun 1;16(11):3590-600. doi: 10.1523/JNEUROSCI.16-11-03590.1996.
本文引用的文献
1
Transcriptional modulation of platelet-activating factor receptor gene expression by cyclic AMP.环磷酸腺苷对血小板活化因子受体基因表达的转录调控
J Biol Chem. 1993 Aug 15;268(23):17457-62.
2
Platelet-activating factor: receptors and signal transduction.血小板活化因子：受体与信号转导
Biochem J. 1993 Jun 15;292 ( Pt 3)(Pt 3):617-29. doi: 10.1042/bj2920617.
3
Two different promoters direct expression of two distinct forms of mRNAs of human platelet-activating factor receptor.两种不同的启动子指导人血小板活化因子受体两种不同形式的mRNA的表达。
FEBS Lett. 1993 May 10;322(2):129-34. doi: 10.1016/0014-5793(93)81552-b.
4
Lipopolysaccharide nonresponder cells: the C3H/HeJ defect.脂多糖无反应细胞：C3H/HeJ缺陷
Immunobiology. 1993 Apr;187(3-5):257-71. doi: 10.1016/S0171-2985(11)80343-8.
5
Two distinct signal transduction pathways for the activation of guinea-pig macrophages and neutrophils by endotoxin.内毒素激活豚鼠巨噬细胞和中性粒细胞的两条不同信号转导途径。
Biochem Biophys Res Commun. 1993 Dec 15;197(2):465-72. doi: 10.1006/bbrc.1993.2502.
6
IFN-gamma up-regulates platelet-activating factor receptor gene expression in human monocytes.γ干扰素上调人单核细胞中血小板活化因子受体基因的表达。
J Immunol. 1994 May 15;152(10):5092-9.
7
Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA.大鼠血小板活化因子受体cDNA的克隆、表达及组织分布
Eur J Biochem. 1994 Apr 1;221(1):211-8. doi: 10.1111/j.1432-1033.1994.tb18731.x.
8
Bacterial endotoxin: molecular relationships of structure to activity and function.细菌内毒素：结构与活性及功能的分子关系
FASEB J. 1994 Feb;8(2):217-25. doi: 10.1096/fasebj.8.2.8119492.
9
Dimethyl sulfoxide modulates NF-kappa B and cytokine activation in lipopolysaccharide-treated murine macrophages.二甲基亚砜调节脂多糖处理的小鼠巨噬细胞中NF-κB和细胞因子的激活。
Infect Immun. 1994 Aug;62(8):3122-8. doi: 10.1128/iai.62.8.3122-3128.1994.
10
Construction of a BALB/c congenic mouse, C.C3H-Lpsd, that expresses the Lpsd allele: analysis of chromosome 4 markers surrounding the Lps gene.表达Lpsd等位基因的BALB/c同源近交系小鼠C.C3H-Lpsd的构建：Lps基因周围4号染色体标记的分析
Infect Immun. 1994 Oct;62(10):4454-9. doi: 10.1128/iai.62.10.4454-4459.1994.
Zotero 插件