来自海洋鱼类肠道内容物的弧菌分离株中新型依赖镁离子的土霉素抗性决定子tet 34
New Mg2+-dependent oxytetracycline resistance determinant tet 34 in Vibrio isolates from marine fish intestinal contents.
作者信息
Nonaka Lisa, Suzuki Satoru
机构信息
Center for Marine Environmental Studies (CMES), Ehime University, Matsuyama 790-8577, Japan.
出版信息
Antimicrob Agents Chemother. 2002 May;46(5):1550-2. doi: 10.1128/AAC.46.5.1550-1552.2002.
Abstract
A new oxytetracycline (OTC) resistance (Otc(r)) determinant, Tet 34, was cloned from chromosomal DNA of Vibrio sp. no. 6 isolated from intestinal contents of cultured yellowtail (Seriola quinqueradiata). The transformant, containing cloned Tet 34, could grow in broth containing 25 microg of drug per ml with 10 mM MgCl2. Tet 34 encoded an open reading frame (ORF) 154 amino acids long. The amino acid sequence of the ORF was homologous to sequences of several bacterial xanthine-guanine phosphoribosyltransferases (XPRTs), which act in purine nucleotide salvage synthesis. Mg2+ binding site residues and the active site were highly conserved in XPRT and the ORF of Tet 34. The results suggest that Tet 34 encodes a new Mg2+-dependent Otc(r) mechanism.
摘要
从养殖黄尾鱼（Seriola quinqueradiata）肠道内容物中分离出的弧菌属6号菌株的染色体DNA中克隆出一种新的土霉素（OTC）抗性（Otc(r)）决定簇Tet 34。含有克隆的Tet 34的转化体能够在每毫升含有25微克药物并添加10 mM氯化镁的肉汤中生长。Tet 34编码一个长度为154个氨基酸的开放阅读框（ORF）。该ORF的氨基酸序列与几种细菌黄嘌呤-鸟嘌呤磷酸核糖转移酶（XPRT）的序列同源，这些酶参与嘌呤核苷酸补救合成。Mg2+结合位点残基和活性位点在XPRT和Tet 34的ORF中高度保守。结果表明，Tet 34编码一种新的依赖Mg2+的Otc(r)机制。
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1
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Appl Environ Microbiol. 2000 Nov;66(11):4908-15. doi: 10.1128/AEM.66.11.4908-4915.2000.
2
Distribution and in-vitro transfer of tetracycline resistance determinants in clinical and aquatic Acinetobacter strains.临床和水生不动杆菌菌株中四环素抗性决定因素的分布及体外转移
J Med Microbiol. 2000 Oct;49(10):929-936. doi: 10.1099/0022-1317-49-10-929.
3
Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS.蚜虫内共生细菌布赫纳氏菌（Buchnera sp.）APS的基因组序列。
Nature. 2000 Sep 7;407(6800):81-6. doi: 10.1038/35024074.
4
Distribution of oxytetracycline resistance plasmids between aeromonads in hospital and aquaculture environments: implication of Tn1721 in dissemination of the tetracycline resistance determinant tet A.医院和水产养殖环境中气单胞菌之间土霉素抗性质粒的分布：Tn1721在四环素抗性决定簇tet A传播中的作用
Appl Environ Microbiol. 2000 Sep;66(9):3883-90. doi: 10.1128/AEM.66.9.3883-3890.2000.
5
DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae.霍乱病原体霍乱弧菌两条染色体的DNA序列。
Nature. 2000 Aug 3;406(6795):477-83. doi: 10.1038/35020000.
6
Antibacterial effect of chloramphenicol, thiamphenicol and florfenicol against aquatic animal bacteria.氯霉素、甲砜霉素和氟苯尼考对水生动物细菌的抗菌作用。
J Vet Med Sci. 2000 May;62(5):479-85. doi: 10.1292/jvms.62.479.
7
Nomenclature for new tetracycline resistance determinants.新型四环素抗性决定簇的命名法。
Antimicrob Agents Chemother. 1999 Jun;43(6):1523-4. doi: 10.1128/AAC.43.6.1523.
8
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Appl Environ Microbiol. 1998 Nov;64(11):4194-201. doi: 10.1128/AEM.64.11.4194-4201.1998.
9
Crystal structure of Escherichia coli xanthine phosphoribosyltransferase.大肠杆菌黄嘌呤磷酸核糖转移酶的晶体结构
Biochemistry. 1997 Apr 8;36(14):4125-34. doi: 10.1021/bi962640d.
10
Regionally-targeted mutagenesis by metabolically-activated steviol: DNA sequence analysis of steviol-induced mutants of guanine phosphoribosyltransferase (gpt) gene of Salmonella typhimurium TM677.
Mutagenesis. 1996 Nov;11(6):565-72. doi: 10.1093/mutage/11.6.565.
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