在实验性脑膜炎中，吉米沙星对耐青霉素和耐喹诺酮的肺炎球菌有效。
Gemifloxacin is efficacious against penicillin-resistant and quinolone-resistant pneumococci in experimental meningitis.
作者信息
Cottagnoud Philippe, Acosta Fernando, Cottagnoud Marianne, Täuber Martin G
机构信息
Department of Internal Medicine, Inselspital, University of Bern, 3010 Bern, Switzerland.
出版信息
Antimicrob Agents Chemother. 2002 May;46(5):1607-9. doi: 10.1128/AAC.46.5.1607-1609.2002.
Abstract
In experimental rabbit meningitis, gemifloxacin penetrated inflamed meninges well (22 to 33%) and produced excellent bactericidal activity (change in log(10) [Deltalog(10)] CFU/ml/h, -0.68 +/- 0.30 [mean and standard deviation]), even superior to that of the standard regimen of ceftriaxone plus vancomycin (-0.49 +/- 0.09 deltalog(10) CFU/ml/h), in the treatment of meningitis due to a penicillin-resistant pneumococcal strain (MIC, 4 mg/liter). Even against a penicillin- and quinolone-resistant strain, gemifloxacin showed good bactericidal activity (-0.48 +/- 0.16 deltalog(10) CFU/ml/h). The excellent antibacterial activity of gemifloxacin was also confirmed by time-kill assays over 8 h in vitro.
摘要
在实验性兔脑膜炎中，吉米沙星能很好地穿透发炎的脑膜（22%至33%），并产生出色的杀菌活性（每小时log(10) [Δlog(10)] CFU/ml的变化，-0.68±0.30 [平均值和标准差]），在治疗由对青霉素耐药的肺炎球菌菌株（MIC，4毫克/升）引起的脑膜炎时，其杀菌活性甚至优于头孢曲松加万古霉素的标准方案（-0.49±0.09 Δlog(10) CFU/ml/h）。即使针对对青霉素和喹诺酮耐药的菌株，吉米沙星也显示出良好的杀菌活性（-0.48±0.16 Δlog(10) CFU/ml/h）。吉米沙星的出色抗菌活性也通过体外8小时的时间杀菌试验得到证实。
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