曲伐沙星联合万古霉素治疗兔脑膜炎模型中耐青霉素肺炎球菌的研究
Trovafloxacin in combination with vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model.
作者信息
Rodoni D, Hänni F, Gerber C M, Cottagnoud M, Neftel K, Täuber M G, Cottagnoud P
机构信息
Department of Internal Medicine, Inselspital, Berne, Switzerland.
出版信息
Antimicrob Agents Chemother. 1999 Apr;43(4):963-5. doi: 10.1128/AAC.43.4.963.
Abstract
Trovafloxacin, a new fluoroquinolone, produced bactericidal activity (-0.33 +/- 0.13 delta log10 CFU/ml.h; intravenously [i.v.] administered dose, 15 mg/kg) comparable to that of vancomycin (-0.39 +/- 0.18 delta log10 CFU/ml.h; i.v. admininistered dose, 20 mg/kg) in the treatment of experimental meningitis in rabbits due to a pneumococcal strain highly resistant to penicillin (MIC of penicillin G, 4 micrograms/ml). The combination of both drugs significantly increased (P < 0.05) the killing rate (-0.60 +/- 0.23 delta log10 CFU/ml.h) compared to that produced by either monotherapy. These results were also confirmed in vitro.
摘要
曲伐沙星是一种新型氟喹诺酮类药物，在治疗由对青霉素高度耐药的肺炎球菌菌株（青霉素G的MIC为4微克/毫升）引起的兔实验性脑膜炎时，其产生的杀菌活性（-0.33±0.13对数10CFU/毫升·小时；静脉注射[i.v.]剂量为15毫克/千克）与万古霉素（-0.39±0.18对数10CFU/毫升·小时；静脉注射剂量为20毫克/千克）相当。与单一疗法相比，两种药物联合使用显著提高（P<0.05）了杀菌率（-0.60±0.23对数10CFU/毫升·小时）。这些结果在体外也得到了证实。
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