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利奈唑胺对艰难梭菌的体外活性。

In vitro activity of linezolid against Clostridium difficile.

作者信息

Peláez T, Alonso R, Pérez C, Alcalá L, Cuevas O, Bouza E

机构信息

Microbiology and Infectious Diseases Service, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

出版信息

Antimicrob Agents Chemother. 2002 May;46(5):1617-8. doi: 10.1128/AAC.46.5.1617-1618.2002.

DOI:10.1128/AAC.46.5.1617-1618.2002
PMID:11959617
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC127182/
Abstract

We examined the in vitro activity of linezolid against Clostridium difficile, including isolates with reduced susceptibility to metronidazole or vancomycin. The MIC at which 50% of the isolates were inhibited (MIC50) and MIC90 were 0.5 and 2 microg/ml, respectively (range, 0.03 to 4 microg/ml). MICs were always <or= 4 microg/ml, and thus, all isolates were considered susceptible.

摘要

我们检测了利奈唑胺对艰难梭菌的体外活性，包括对甲硝唑或万古霉素敏感性降低的分离株。50%的分离株被抑制时的最低抑菌浓度（MIC50）和MIC90分别为0.5和2微克/毫升（范围为0.03至4微克/毫升）。MIC值始终≤4微克/毫升，因此，所有分离株均被视为敏感。

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