新型酮内酯 RBx 14255 对艰难梭菌的体外和体内活性。
In vitro and in vivo activities of the novel Ketolide RBx 14255 against Clostridium difficile.
机构信息
Department of Infectious Diseases, New Drug Discovery Research, Ranbaxy Research Laboratories, Gurgaon, India.
出版信息
Antimicrob Agents Chemother. 2012 Nov;56(11):5986-9. doi: 10.1128/AAC.00015-12. Epub 2012 Aug 6.
Abstract
The MIC(90) of RBx 14255, a novel ketolide, against Clostridium difficile was 4 μg/ml (MIC range, 0.125 to 8 μg/ml), and this drug was found to be more potent than comparator drugs. An in vitro time-kill kinetics study of RBx 14255 showed time-dependent bacterial killing for C. difficile. Furthermore, in the hamster model of C. difficile infection, RBx 14255 demonstrated greater efficacy than metronidazole and vancomycin, making it a promising candidate for C. difficile treatment.
摘要
新型酮内酯 RBx 14255 对艰难梭菌的 MIC(90)为 4 μg/ml（MIC 范围为 0.125 至 8 μg/ml），该药物的活性强于对照药物。RBx 14255 的体外时间杀菌动力学研究显示，其对艰难梭菌具有时间依赖性杀菌作用。此外，在艰难梭菌感染的仓鼠模型中，RBx 14255 的疗效优于甲硝唑和万古霉素，使其成为艰难梭菌治疗的有希望的候选药物。
相似文献
1
In vitro and in vivo activities of the novel Ketolide RBx 14255 against Clostridium difficile.新型酮内酯 RBx 14255 对艰难梭菌的体外和体内活性。
Antimicrob Agents Chemother. 2012 Nov;56(11):5986-9. doi: 10.1128/AAC.00015-12. Epub 2012 Aug 6.
2
In vitro and in vivo antibacterial evaluation of cadazolid, a new antibiotic for treatment of Clostridium difficile infections.体外和体内抗菌评估卡他唑，一种新的抗生素治疗艰难梭菌感染。
Antimicrob Agents Chemother. 2014;58(2):892-900. doi: 10.1128/AAC.01830-13. Epub 2013 Nov 25.
3
In vitro activities of CB-183,315, vancomycin, and metronidazole against 556 strains of Clostridium difficile, 445 other intestinal anaerobes, and 56 Enterobacteriaceae species.体外研究 CB-183,315、万古霉素和甲硝唑对 556 株艰难梭菌、445 株其他肠道厌氧菌和 56 株肠杆菌科细菌的活性。
Antimicrob Agents Chemother. 2012 Mar;56(3):1613-5. doi: 10.1128/AAC.05655-11. Epub 2011 Dec 19.
4
MBX-500, a hybrid antibiotic with in vitro and in vivo efficacy against toxigenic Clostridium difficile.MBX-500，一种具有针对产毒艰难梭菌的体外和体内疗效的混合抗生素。
Antimicrob Agents Chemother. 2012 Sep;56(9):4786-92. doi: 10.1128/AAC.00508-12. Epub 2012 Jun 25.
5
Fluoroquinolone resistance and Clostridium difficile, Germany.氟喹诺酮类药物耐药与艰难梭菌，德国。
Emerg Infect Dis. 2010 Apr;16(4):675-7. doi: 10.3201/eid1604.090859.
6
Reassessment of Clostridium difficile susceptibility to metronidazole and vancomycin.艰难梭菌对甲硝唑和万古霉素敏感性的重新评估。
Antimicrob Agents Chemother. 2002 Jun;46(6):1647-50. doi: 10.1128/AAC.46.6.1647-1650.2002.
7
In vitro activity of linezolid against Clostridium difficile.利奈唑胺对艰难梭菌的体外活性。
Antimicrob Agents Chemother. 2002 May;46(5):1617-8. doi: 10.1128/AAC.46.5.1617-1618.2002.
8
Analysis of anti-Clostridium difficile activity of thuricin CD, vancomycin, metronidazole, ramoplanin, and actagardine, both singly and in paired combinations.分析单独及联合使用时，短小杆菌素 CD、万古霉素、甲硝唑、瑞他莫林和 actagardine 对艰难梭菌的抑制活性。
Antimicrob Agents Chemother. 2013 Jun;57(6):2882-6. doi: 10.1128/AAC.00261-13. Epub 2013 Apr 9.
9
In vitro and in vivo characterization of CB-183,315, a novel lipopeptide antibiotic for treatment of Clostridium difficile.新型脂肽类抗生素 CB-183,315 的体外和体内特性研究，用于治疗艰难梭菌感染。
Antimicrob Agents Chemother. 2012 Oct;56(10):5023-30. doi: 10.1128/AAC.00057-12. Epub 2012 Jul 16.
10
In vitro and in vivo activities of nitazoxanide against Clostridium difficile.硝唑尼特对艰难梭菌的体外和体内活性
Antimicrob Agents Chemother. 2000 Sep;44(9):2254-8. doi: 10.1128/AAC.44.9.2254-2258.2000.
引用本文的文献
1
and Antibacterial Activities of a Novel Quinolone Compound, OPS-2071, against Clostridioides difficile.新型喹诺酮化合物OPS-2071对艰难梭菌的抗菌活性
Antimicrob Agents Chemother. 2021 Mar 18;65(4). doi: 10.1128/AAC.01170-20.
2
and Activities of DS-2969b, a Novel GyrB Inhibitor, against Clostridium difficile.新型拓扑异构酶 II 抑制剂 DS-2969b 对艰难梭菌的活性研究。
Antimicrob Agents Chemother. 2018 Mar 27;62(4). doi: 10.1128/AAC.02157-17. Print 2018 Apr.
3
A Review of Experimental and Off-Label Therapies for Clostridium difficile Infection.艰难梭菌感染的实验性和非标签疗法综述
Infect Dis Ther. 2017 Mar;6(1):1-35. doi: 10.1007/s40121-016-0140-z. Epub 2016 Dec 1.
4
Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review.艰难梭菌感染治疗方法的研究进展：临床和药物化学综述。
Curr Top Med Chem. 2014;14(1):152-75. doi: 10.2174/1568026613666131113154753.
本文引用的文献
1
Activity of RBx 11760, a novel biaryl oxazolidinone, against Clostridium difficile.新型联苯恶唑烷酮 RBx 11760 对艰难梭菌的活性。
J Antimicrob Chemother. 2011 May;66(5):1087-95. doi: 10.1093/jac/dkr033. Epub 2011 Mar 3.
2
Activity of a novel series of acylides active against community-acquired respiratory pathogens.针对社区获得性呼吸道病原体的新型酰基化物系列的活性。
Int J Antimicrob Agents. 2010 Aug;36(2):169-74. doi: 10.1016/j.ijantimicag.2010.03.026. Epub 2010 May 20.
3
Clostridium difficile associated infection, diarrhea and colitis.艰难梭菌相关性感染、腹泻和结肠炎。
World J Gastroenterol. 2009 Apr 7;15(13):1554-80. doi: 10.3748/wjg.15.1554.
4
New trends in Clostridium difficile virulence and pathogenesis.艰难梭菌毒力与发病机制的新趋势
Int J Antimicrob Agents. 2009 Mar;33 Suppl 1:S24-8. doi: 10.1016/S0924-8579(09)70012-3.
5
Toxin B is essential for virulence of Clostridium difficile.毒素B对于艰难梭菌的毒力至关重要。
Nature. 2009 Apr 30;458(7242):1176-9. doi: 10.1038/nature07822. Epub 2009 Mar 1.
6
Inhibitory effect of REP3123 on toxin and spore formation in Clostridium difficile, and in vivo efficacy in a hamster gastrointestinal infection model.REP3123对艰难梭菌毒素和孢子形成的抑制作用以及在仓鼠胃肠道感染模型中的体内疗效。
J Antimicrob Chemother. 2009 May;63(5):964-71. doi: 10.1093/jac/dkp042. Epub 2009 Feb 26.
7
Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.瑞贝唑胺对葡萄球菌的作用机制及其与核糖体相互作用的结构建模研究
Antimicrob Agents Chemother. 2009 Apr;53(4):1427-33. doi: 10.1128/AAC.00887-08. Epub 2008 Dec 15.
8
Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis.通过最低抑菌浓度（MIC）和时间-杀菌分析测定多利培南的抗厌氧活性比较
Antimicrob Agents Chemother. 2008 Jan;52(1):365-73. doi: 10.1128/AAC.00910-07. Epub 2007 Oct 15.
9
A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity.万古霉素与甲硝唑治疗艰难梭菌相关性腹泻的比较，按疾病严重程度分层
Clin Infect Dis. 2007 Aug 1;45(3):302-7. doi: 10.1086/519265. Epub 2007 Jun 19.
10
Clostridium difficile among hospitalized patients receiving antibiotics: a case-control study.接受抗生素治疗的住院患者中的艰难梭菌：一项病例对照研究。
Infect Control Hosp Epidemiol. 2005 Aug;26(8):685-90. doi: 10.1086/502603.
Zotero 插件