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体外研究 CB-183,315、万古霉素和甲硝唑对 556 株艰难梭菌、445 株其他肠道厌氧菌和 56 株肠杆菌科细菌的活性。

In vitro activities of CB-183,315, vancomycin, and metronidazole against 556 strains of Clostridium difficile, 445 other intestinal anaerobes, and 56 Enterobacteriaceae species.

机构信息

RM Alden Research Lab, Culver City, California, USA.

出版信息

Antimicrob Agents Chemother. 2012 Mar;56(3):1613-5. doi: 10.1128/AAC.05655-11. Epub 2011 Dec 19.

DOI:10.1128/AAC.05655-11
PMID:22183166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3294948/
Abstract

MICs of CB-183,315, a novel lipopeptide antibiotic, vancomycin, and metronidazole were determined for intestinal anaerobes and Enterobacteriaceae. The MIC(90)s for Gram-negative anaerobes were >8,192, 8,192, and 4 μg/ml for CB-183,315, vancomycin, and metronidazole, respectively. Against Enterobacteriaceae, the MIC(90)s were >8,192 μg/ml, 1,024 μg/ml, and 1,024 μg/ml, respectively. The CB-183,315 MIC(90) for Clostridium difficile was 0.5 μg/ml. Its lack of activity against normal fecal organisms makes it a promising new agent for treating C. difficile.

摘要

CB-183,315 是一种新型脂肽类抗生素，我们测定了其对肠道厌氧菌和肠杆菌科的最低抑菌浓度（MIC）。对革兰氏阴性厌氧菌而言，CB-183,315、万古霉素和甲硝唑的 MIC(90)分别为>8,192、8,192 和 4 μg/ml。对肠杆菌科，MIC(90)分别为>8,192 μg/ml、1,024 μg/ml 和 1,024 μg/ml。CB-183,315 对艰难梭菌的 MIC(90)为 0.5 μg/ml。它对正常粪便微生物无活性，这使其成为治疗艰难梭菌的一种有前途的新型药物。

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本文引用的文献

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Management of Clostridium difficile infection: thinking inside and outside the box.艰难梭菌感染的管理：跳出固有思维。
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A new macrocyclic antibiotic, fidaxomicin (OPT-80), causes less alteration to the bowel microbiota of Clostridium difficile-infected patients than does vancomycin.一种新型大环抗生素，非达霉素（OPT-80），相较于万古霉素，引起艰难梭菌感染患者肠道微生物群改变更小。
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Lack of increased colonization with vancomycin-resistant enterococci during preferential use of vancomycin for treatment during an outbreak of healthcare-associated Clostridium difficile infection.在医疗机构相关性艰难梭菌感染爆发期间，优先使用万古霉素治疗时，并未发现万古霉素耐药肠球菌定植增加。
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