D'Arbe M, Einstein R, Lavidis N A
The Department of Physiology and Pharmacology, The School of Biomedical Sciences, The University of Queensland, St. Lucia, Brisbane, Queensland 4072, Australia.
Am J Physiol Regul Integr Comp Physiol. 2002 May;282(5):R1422-8. doi: 10.1152/ajpregu.00805.2000.
Although the sympathetic nervous system (SNS) plays a major role in mediating the peripheral stress response, due consideration is not usually given to the effects of prolonged stress on the SNS. The present study examined changes in neurotransmission in the SNS after exposure of mice (BALB/c) to stressful housing conditions. Focal extracellular recording of excitatory junction currents (EJCs) was used as a relative measure of neurotransmitter release from different regions of large surface areas of the mouse vas deferens. Mice were either group housed (control), isolation housed (social deprivation), group housed in a room containing rats (rat odor stress), or isolation housed in a room containing rats (concurrent stress). Social deprivation and concurrent stressors induced an increase of 30 and 335% in EJC amplitude, respectively. The success rate of recording EJCs from sets of varicosities in the concurrent stressor group was greater compared with all other groups. The present study has shown that some common animal housing conditions act as stressors and induce significant changes in sympathetic neurotransmission.
尽管交感神经系统（SNS）在介导外周应激反应中起主要作用，但人们通常并未充分考虑长期应激对交感神经系统的影响。本研究检测了将小鼠（BALB/c）置于应激性饲养条件下后交感神经系统中神经传递的变化。兴奋性接头电流（EJC）的局灶性细胞外记录被用作小鼠输精管大表面积不同区域神经递质释放的相对测量指标。小鼠被分为群居（对照）、单独饲养（社会剥夺）、与大鼠同室群居（大鼠气味应激）或与大鼠同室单独饲养（并发应激）。社会剥夺和并发应激源分别使EJC幅度增加了30%和335%。与所有其他组相比，并发应激源组从一组曲张体记录EJC的成功率更高。本研究表明，一些常见的动物饲养条件会成为应激源，并引起交感神经传递的显著变化。
