Vasudev A, Tripathi K D, Puri V
Department of Pharmacology, Maulana Azad Medical College, New Delhi, 110002, India.
Neurol India. 2002 Mar;50(1):60-2.
Therapeutic drug monitoring (TDM) of carbamazepine (CBZ) in saliva is an attractive alternative, because its collection is painless, non-invasive and simpler than drawing blood. Salivary drug levels, also closely reflect the free drug concentration. The aim of the study was to evaluate the suitability of saliva in routine TDM of CBZ in adult epileptic patients. Blood and saliva samples were taken simultaneously at 0 hours and 24 hours of CBZ dosing from 31 epileptic patients, receiving CBZ monotherapy for three or more months. Levels of CBZ in both these fluids were measured by high performance liquid chromatography. Strong and highly significant correlation was found between serum and salivary CBZ concentration (r = 0.659, p<0.001). Estimation of CBZ level in saliva is thus a practicable, valid and convenient method of TDM in epileptic patients.
唾液中卡马西平（CBZ）的治疗药物监测（TDM）是一种颇具吸引力的替代方法，因为其采集过程无痛、无创，且比抽血更简便。唾液中的药物水平也能密切反映游离药物浓度。本研究的目的是评估唾液在成年癫痫患者CBZ常规TDM中的适用性。在31例接受CBZ单药治疗三个月或更长时间的癫痫患者中，于CBZ给药后0小时和24小时同时采集血液和唾液样本。通过高效液相色谱法测定这两种体液中CBZ的水平。血清和唾液中CBZ浓度之间存在强且高度显著的相关性（r = 0.659，p<0.001）。因此，估算唾液中CBZ水平是癫痫患者TDM的一种可行、有效且便捷的方法。
