心力衰竭的预防。

Prevention of heart failure.

作者信息

Horwich Tamara B, Fonarow Gregg C

机构信息

Ahmanson-UCLA Cardiomyopathy Center, Division of Cardiology, 47-123 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095-1679, USA.

出版信息

Curr Cardiol Rep. 2002 May;4(3):194-9. doi: 10.1007/s11886-002-0050-4.

DOI:10.1007/s11886-002-0050-4

PMID:11960587

Abstract

In light of the increasing prevalence, morbidity, and mortality of heart failure, preventative strategies are urgently needed. Risk factors include coronary artery disease, renal insufficiency, diabetes, and smoking. Essential strategies for prevention of heart failure are modification of risk factors for its development, and detection and treatment of asymptomatic left ventricular dysfunction (ALVD). In patients with ALVD, angiotensin-converting enzyme (ACE) inhibitor and beta-blocker therapy can prevent progression to symptomatic heart failure. Additional recently identified preventative strategies include ACE inhibitor therapy for all coronary artery disease and diabetic patients, clopidogrel therapy in acute coronary syndromes, and avoidance of calcium channel blockers and alpha-blockers as first-line antihypertensive therapy.

摘要

鉴于心力衰竭的患病率、发病率和死亡率不断上升，迫切需要预防策略。危险因素包括冠状动脉疾病、肾功能不全、糖尿病和吸烟。预防心力衰竭的基本策略是改变其发生的危险因素，以及检测和治疗无症状左心室功能障碍（ALVD）。对于ALVD患者，血管紧张素转换酶（ACE）抑制剂和β受体阻滞剂治疗可预防进展为有症状的心力衰竭。最近确定的其他预防策略包括对所有冠状动脉疾病和糖尿病患者进行ACE抑制剂治疗、急性冠状动脉综合征中的氯吡格雷治疗，以及避免将钙通道阻滞剂和α受体阻滞剂作为一线抗高血压治疗药物。