Wadsworth P F, Heywood R, Allen D G, Hossack D J, Sortwell R J, Walton R M
Contraception. 1979 Dec;20(6):559-67. doi: 10.1016/s0010-7824(79)80035-9.
The effects of levonorgestrel-releasing intravaginal rings were investigated in 15 rhesus monkeys for 52 weeks. The intravaginal rings were designed to provide a sustained release of either three or ten times the human dose level of the hormone. Untreated placebo rings were used as a control. The devices were well retained. After insertion of the vaginal rings, a dose-related decrease in vaginal bleeding was observed. The vaginal microbial flora were assessed qualitatively and semi-quantitatively and although all groups including controls showed some changes in microbial populations, by the end of the study nearly all animals returned to a normal balanced microflora. Terminal studies showed that, at the high dose level, ovulation was suppressed and widespread atrophy of the uterine mucosal and glandular epithelium had occurred. A dose-related increase in mucus within the lumen of the endocervical canal was observed. Focal or diffuse atrophy of the vaginal mucosal epithelium was seen in the majority of levonorgestrel-treated animals.
在15只恒河猴身上对左炔诺孕酮阴道环的效果进行了为期52周的研究。阴道环的设计目的是持续释放相当于人类剂量水平3倍或10倍的激素。未治疗的安慰剂环用作对照。这些装置保留良好。插入阴道环后，观察到阴道出血呈剂量相关减少。对阴道微生物群进行了定性和半定量评估，尽管包括对照组在内的所有组的微生物种群都有一些变化，但在研究结束时，几乎所有动物都恢复到了正常的平衡微生物群。终末研究表明，在高剂量水平下，排卵受到抑制，子宫黏膜和腺上皮出现广泛萎缩。观察到宫颈管腔内黏液呈剂量相关增加。在大多数接受左炔诺孕酮治疗的动物中，可见阴道黏膜上皮局灶性或弥漫性萎缩。
