Wadsworth P F, Heywood R, Allen D G, Sortwell R J, Walton R M
Contraception. 1979 Aug;20(2):177-84. doi: 10.1016/0010-7824(79)90090-8.
The effects of levonorgestrel-loaded plastic intrauterine devices on endometrial morphology were investigated in 15 rhesus monkeys for 14 weeks. The devices were designed to release 25 microgram of the hormone per day and were inserted in the uterus by hysterotomy. Control animals were sham operated or received inert placebo devices. With the levonorgestrel-releasing devices, widespread changes in endometrial morphology were seen. These changes included atrophy of the endometrial mucosal and glandular epithelium and decidualization of the endometrial stroma. With the inert placebo control devices, only minor changes in endometrial morphology were observed.
在15只恒河猴中研究了含左炔诺孕酮的塑料宫内节育器对子宫内膜形态的影响，为期14周。这些节育器设计为每天释放25微克该激素，通过子宫切开术将其置入子宫。对照动物接受假手术或置入惰性安慰剂节育器。使用释放左炔诺孕酮的节育器时，可见子宫内膜形态发生广泛变化。这些变化包括子宫内膜黏膜和腺上皮萎缩以及子宫内膜基质蜕膜化。使用惰性安慰剂对照节育器时，仅观察到子宫内膜形态有轻微变化。
