Wadsworth P F, Lewis D J, Heywood R
Contraception. 1980 Aug;22(2):189-98. doi: 10.1016/0010-7824(80)90063-3.
Five rhesus monkeys were treated with levonorgestrel-releasing intravaginal rings for 52 weeks. The rings were designed to provide a sustained release of ten times the human dose level of the hormone. Histological examination of the uterine endometrium showed widespread decidualisation of endometrial stromal cells. Ultrastructurally, two distinct cell types were identified: decidual and granular. Some of the decidual cells were ultrastructurally comparable with those reported elsewhere; however, in aproportion of these cells, intracisternal sequestration of the rough endoplasmic reticulum was widespread. The granular cells resembled those described in the metrial gland of rats and, as their name suggests, contained variable numbers of electron-dense granules.
五只恒河猴接受了含左炔诺孕酮的阴道环治疗，为期52周。这些环被设计为能持续释放相当于人类剂量水平10倍的激素。对子宫内膜进行组织学检查发现，子宫内膜基质细胞广泛蜕膜化。在超微结构上，识别出两种不同的细胞类型：蜕膜细胞和颗粒细胞。一些蜕膜细胞在超微结构上与其他地方报道的细胞相似；然而，在这些细胞的一部分中，粗面内质网的池内隔离现象很普遍。颗粒细胞类似于大鼠蜕膜腺中描述的细胞，顾名思义，含有数量不等的电子致密颗粒。
