Nieman David C, Henson Dru A, McAnulty Steve R, McAnulty Lisa, Swick Nathaniel S, Utter Alan C, Vinci Debra M, Opiela Shannon J, Morrow Jason D
Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, North Carolina 28608, USA.
J Appl Physiol (1985). 2002 May;92(5):1970-7. doi: 10.1152/japplphysiol.00961.2001.
The purpose of this randomized study was to measure the influence of vitamin C (n = 15 runners) compared with placebo (n = 13 runners) supplementation on oxidative and immune changes in runners competing in an ultramarathon race. During the 7-day period before the race and on race day, subjects ingested in randomized, double-blind fashion 1,500 mg/day vitamin C or placebo. On race day, blood samples were collected 1 h before race, after 32 km of running, and then again immediately after race. Subjects in both groups maintained an intensity of approximately 75% maximal heart rate throughout the ultramarathon race and ran a mean of 69 km (range: 48-80 km) in 9.8 h (range: 5-12 h). Plasma ascorbic acid was markedly higher in the vitamin C compared with placebo group prerace and rose more strongly in the vitamin C group during the race (postrace: 3.21 +/- 0.29 and 1.28 +/- 0.12 microg/100 microl, respectively, P < 0.001). No significant group or interaction effects were measured for lipid hydroperoxide, F2-isoprostane, immune cell counts, plasma interleukin (IL)-6, IL-10, IL-1-receptor antagonist, or IL-8 concentrations, or mitogen-stimulated lymphocyte proliferation and IL-2 and IFN-gamma production. These data indicate that vitamin C supplementation in carbohydrate-fed runners does not serve as a countermeasure to oxidative and immune changes during or after a competitive ultramarathon race.
这项随机研究的目的是，比较补充维生素C（n = 15名跑步者）与补充安慰剂（n = 13名跑步者）对参加超级马拉松比赛的跑步者氧化和免疫变化的影响。在比赛前7天和比赛当天，受试者以随机、双盲的方式摄入1500毫克/天的维生素C或安慰剂。在比赛当天，于比赛前1小时、跑了32公里后以及比赛结束后立即采集血样。两组受试者在整个超级马拉松比赛中均保持约75%最大心率的强度，平均跑了69公里（范围：48 - 80公里），用时9.8小时（范围：5 - 12小时）。与安慰剂组相比，维生素C组赛前血浆抗坏血酸明显更高，且在比赛期间维生素C组升高更为显著（赛后分别为：3.21±0.29和1.28±0.12微克/100微升，P < 0.001）。对于脂质过氧化氢、F2 -异前列腺素、免疫细胞计数、血浆白细胞介素（IL）-6、IL - 10、IL - 1受体拮抗剂或IL - 8浓度，以及丝裂原刺激的淋巴细胞增殖和IL - 2及IFN -γ产生，未检测到显著的组间或交互作用效应。这些数据表明，在摄入碳水化合物的跑步者中补充维生素C，并不能作为应对竞争性超级马拉松比赛期间或之后氧化和免疫变化的对策。
