Habtu E, Gill G, Tesfaye S
Mekelle Hospital, Tigray, Ethiopia.
Ethiop Med J. 1999 Oct;37(4):263-7.
We have examined 100 consecutive insulin-treated diabetic patients from the Diabetic Clinic at Mekelle Hospital in Tigray, Northern Ethiopia; an area of low socio-economic status recently affected by severe famine. The study was conducted over a six month period (1997). Mean age of onset of diabetes was 27 +/- 10 y (SD) and there was a male excess (3.1:1.0). Body Mass index (BMI) at diagnosis was very low at 15.8 +/- 2.8. Because of erratic insulin supply 48 (48%) had interrupted insulin treatment in the past for a mean duration of 9 +/- 12 weeks (range 1-78). Despite this, only 2 (4%) developed ketoacidosis (DKA). The patients thus have features suggestive of malnutrition-related diabetes mellitus (MRDM) possibly of the "malnutrition-modulated" (MMDM) type in view of the apparent absence of overt exocrine pancreatic disease. The famine in this area 10 years previously may be of relevance to the aetiology of diabetes in these patients.
我们对来自埃塞俄比亚北部提格雷州梅凯勒医院糖尿病诊所的100例接受胰岛素治疗的糖尿病患者进行了检查；该地区社会经济地位较低，近期遭受了严重饥荒。研究在6个月期间（1997年）进行。糖尿病发病的平均年龄为27±10岁（标准差），男性居多（3.1:1.0）。诊断时的体重指数（BMI）非常低，为15.8±2.8。由于胰岛素供应不稳定，48例（48%）患者过去曾中断胰岛素治疗，平均中断时间为9±12周（范围1 - 78周）。尽管如此，只有2例（4%）发生了酮症酸中毒（DKA）。鉴于明显不存在明显的外分泌胰腺疾病，这些患者具有提示营养不良相关性糖尿病（MRDM）的特征，可能属于“营养不良调节型”（MMDM）。该地区10年前的饥荒可能与这些患者糖尿病的病因有关。
