Jacob N, Gleichmann U, Stadler R
Hautklinik am Klinikum Minden, Portastrasse 7-9, 32423 Minden.
Hautarzt. 2002 Feb;53(2):121-5. doi: 10.1007/s001050100229.
Scleredema adultorum, or Buschke's scleredema, belongs to the group of mucinoses. It is characterised by thickened and indurated skin. Histopathology shows thickened dermis with an infiltration of mucin between swollen collagen bundles. There are reports about many associations with scleredema adultorum, e.g., with diabetes mellitus and multiple myeloma. One case is known with associated primary hyperparathyroidism. For the first time we report a case of scleredema adultorum and secondary hyperparathyroidism, in a 46-year-old patient. Both forms of hyperparathyroidism have increased levels of parathormone. Therefore, these increased levels could have an influence on collagen metabolism.
成人硬肿病，即布施克硬肿病，属于粘蛋白病组。其特征为皮肤增厚和硬结。组织病理学显示真皮增厚，在肿胀的胶原束之间有粘蛋白浸润。有许多关于成人硬肿病相关联情况的报道，例如与糖尿病和多发性骨髓瘤相关。已知有一例与原发性甲状旁腺功能亢进相关。我们首次报告了一例46岁成人硬肿病合并继发性甲状旁腺功能亢进的病例。两种形式的甲状旁腺功能亢进均有甲状旁腺激素水平升高。因此，这些升高的水平可能会对胶原代谢产生影响。
