Tate B J, Kelly J W, Rotstein H
Dermatology Unit, Alfred Hospital, Prahran, Vic, Australia.
Australas J Dermatol. 1996 Aug;37(3):139-42. doi: 10.1111/j.1440-0960.1996.tb01032.x.
Scleredema of Buschke is an uncommon dermatosis characterized by thickened, indurated skin, sometimes with erythema. Histopathology shows thickened dermal collagen with a mild infiltrate of mucin in the deeper dermis. Seven adults with scleredema are presented, four females and three males, and their mean age at diagnosis was 54 years. All had diabetes mellitus for an average of 13 years prior to the onset of scleredema. Complications of diabetes, especially retinopathy (n = 5), neuropathy (n = 4) and peripheral vascular disease (n = 3), were present in five patients. One patient died (cause not established), and another has life-threatening cardiomyopathy. We have no evidence that the scleredema was a significant aetiologic factor in either case, despite published reports of fatalities related to scleredema. Three patients were followed up for more than 1 year and, irrespective of therapy, the scleredema did not resolve in any patient.
布希克硬肿病是一种罕见的皮肤病，其特征为皮肤增厚、变硬，有时伴有红斑。组织病理学显示真皮胶原增厚，真皮深层有轻度粘蛋白浸润。本文报告了7例硬肿病成人患者，其中4例女性，3例男性，诊断时的平均年龄为54岁。所有患者在硬肿病发病前平均患有糖尿病13年。5例患者存在糖尿病并发症，尤其是视网膜病变（n = 5）、神经病变（n = 4）和外周血管疾病（n = 3）。1例患者死亡（死因未明确），另1例患有危及生命的心肌病。尽管有关于硬肿病相关死亡的报道，但我们没有证据表明硬肿病在这两例中是一个重要的病因。3例患者随访超过1年，无论采用何种治疗方法，硬肿病均未在任何患者中消退。
