Piruzian L A, Sukhanov V A, Kalinina E V, Fedorova T Iu, Saprin A N
Center of Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 119991 Russia.
Izv Akad Nauk Ser Biol. 2002 Mar-Apr(2):149-54.
We studied intraspecific features of the main enzymes of metabolism and detoxication of xenobiotics on mice (eight inbred lines) and rats (five lines) for estimation of possible variants of complete or incomplete metabolic equality. Significant genetically determined intraspecific differences for activities of the enzymes of metabolism and detoxication of xenobiotics were described. Generalized criteria for comparison of the metabolic status were proposed on the basis of activities of the main enzymes: cytochrome P-450 (hydroxylation and epoxidation), epoxyhydrolase, glutathione-S-transferase, UDP-glucuronosyl transferase, and sulfotransferase. The proposed criteria for estimation of the metabolic parameters of an individual can serve as a basis of metabolic portraiting.
我们研究了小鼠（8个近交系）和大鼠（5个品系）体内外源性物质代谢和解毒主要酶的种内特征，以评估完全或不完全代谢等同性的可能变体。描述了外源性物质代谢和解毒酶活性的显著遗传决定种内差异。基于主要酶的活性提出了比较代谢状态的通用标准：细胞色素P-450（羟基化和环氧化）、环氧水解酶、谷胱甘肽-S-转移酶、UDP-葡萄糖醛酸基转移酶和磺基转移酶。所提出的评估个体代谢参数的标准可作为代谢描绘的基础。
