Lochmann O, Výmola F, Schneková K, Turková D, Havránková M
Neoplasma. 1975;22(4):431-4.
Besides paraproteins in melanoblastoma, the study also follows the quantitative values of immunoglobulins during the course of the disease. According to the immunoglobulin values, the patients may be divided into two groups: those with a striking decline of IgG and a simultaneous generalization of the process; those without any significant alteration in the immunoglobulin values, but with paraproteins. The presence of the latter, particularly of gM became reflected in a stagnation of the entire process. Immunological results of sera from patients surviving 5 years, bear out this finding.
除了黑色素瘤中的副蛋白外，该研究还跟踪了疾病过程中免疫球蛋白的定量值。根据免疫球蛋白值，患者可分为两组：一组IgG显著下降且病情同时全身扩散；另一组免疫球蛋白值无任何显著变化，但存在副蛋白。后者尤其是IgM的存在反映在整个病情的停滞上。存活5年患者的血清免疫学结果证实了这一发现。
