Daveau M, Pavie-Fischer J, Rivat L, Rivat C, Ropartz C, Peter H H, Cesarini J P, Kourilsky F M
Ann Dermatol Venereol. 1977 Jun-Jul;104(6-7):458-60.
397 sera from 185 melanoma patients have been tested. We classified our subjects into three groups, according to the stage of disease. An alteration of the level of IgG4 subclass was found and related to the extension of the disease. The percentage of abnormalities was more frequent in stage II and III (55 p. 100 and 53 p. 100) than in stage I (19 p. 100). High titers of IgG 4 subclass were essentially detected in advanced disease. The biological significance is discussed.
对185名黑色素瘤患者的397份血清进行了检测。我们根据疾病阶段将研究对象分为三组。发现IgG4亚类水平存在改变，且与疾病进展相关。异常百分比在II期和III期（分别为55%和53%）比I期（19%）更为常见。高滴度的IgG4亚类主要在晚期疾病中检测到。对其生物学意义进行了讨论。
