Salvi S
Department of Respiratory Cell and Molecular Biology Group, University of Southampton, Southampton, UK.
Curr Opin Allergy Clin Immunol. 2001 Feb;1(1):35-41. doi: 10.1097/01.all.0000010982.31993.84.
The incidence of allergic diseases has increased dramatically over recent years in most industrialized countries of the world. Air pollution from motor vehicles has been implicated as one of the factors that are responsible for this increase. Epidemiological studies carried out in different geographical regions in the world have shown a significant and consistent association between ambient levels of pollutants and increased asthma and rhinitis symptoms. Recent human and animal exposure studies, as well as laboratory-based studies, have demonstrated that diesel particles, ozone and nitrogen dioxide induce an inflammatory response that involves various inflammatory cells, mediators and adhesion molecules, which could contribute to worsening of the allergic disorders. The present review describes our current understanding of the mechanisms by which pollutants such as diesel exhaust and ozone enhance the underlying allergic inflammatory response, and possibly explain the associations between pollutants and increasing allergic diseases noted in epidemiological studies.
近年来，在世界上大多数工业化国家，过敏性疾病的发病率急剧上升。机动车排放的空气污染被认为是导致这种上升的因素之一。在世界不同地理区域进行的流行病学研究表明，环境污染物水平与哮喘和鼻炎症状增加之间存在显著且一致的关联。最近的人体和动物暴露研究以及基于实验室的研究表明，柴油颗粒、臭氧和二氧化氮会引发一种炎症反应，涉及各种炎症细胞、介质和黏附分子，这可能导致过敏性疾病恶化。本综述描述了我们目前对柴油废气和臭氧等污染物增强潜在过敏性炎症反应的机制的理解，并可能解释流行病学研究中指出的污染物与过敏性疾病增加之间的关联。
