Notredame Cédric
Information Génétique et Structurale, UMR 1889, 31 Chemin Joseph Aiguier, 13 006 Marseille, France.
Pharmacogenomics. 2002 Jan;3(1):131-44. doi: 10.1517/14622416.3.1.131.
The assembly of a multiple sequence alignment (MSA) has become one of the most common tasks when dealing with sequence analysis. Unfortunately, the wide range of available methods and the differences in the results given by these methods makes it hard for a non-specialist to decide which program is best suited for a given purpose. In this review we briefly describe existing techniques and expose the potential strengths and weaknesses of the most widely used multiple alignment packages.
在进行序列分析时，多序列比对（MSA）的构建已成为最常见的任务之一。不幸的是，可用方法种类繁多，且这些方法给出的结果存在差异，这使得非专业人员很难决定哪种程序最适合特定目的。在本综述中，我们简要描述现有技术，并揭示最广泛使用的多序列比对软件包的潜在优缺点。
