腹膜闭合可减少端口部位转移：大鼠卵巢癌模型实验结果
Peritoneal closure reduces port site metastases: results of an experiment in a rat ovarian cancer model.
作者信息
Agostini A, Robin F, Jais J P, Aggerbeck M, Vildé F, Blanc B, Lécuru F
机构信息
Department of Obstetrics and Gynecology, La Conception University Hospital, 147 Boulevard Baille, 13005, Marseille, France.
出版信息
Surg Endosc. 2002 Feb;16(2):289-91. doi: 10.1007/s00464-001-9063-0. Epub 2001 Nov 12.
BACKGROUND
The arm of this study was to assess the role of peritoneal closure in the prevention of port site metastasis after carbon dioxide (CO2) CO2 pneumoperitoneum.
METHODS
We developed a xenograft ovarian cancer model by intraperitoneal injection of 27 106 IGR-OV1 line cells in nude rats Seven days after the inoculation, the animals underwent a CO2 pneumoperitoneum. At the end of the procedure, port sites were randomly closed either with suture of peritoneum (n = 14, group A) or without suture of peritoneum (n = 12, group B). The rats were killed 7 days after surgery and their port site scars were resected. Tumor implantation was assessed by a pathologist who was blinded to the type of wound closure.
RESULTS
The animals in group B were significantly more likely to have at least one port site metastasis frequent (seven of 12, or 58.3%) than those in group A (two of 14, or (14.3%) (p = 0.037). Port sites with metastases were seen more frequently in group B (eight of 24, or (33.3%) than in group A (three of 28, or 10.7%) (p = 0.046).
CONCLUSIONS
Our results shows that peritoneum closure decreases the risk of port site metastasis.
背景
本研究旨在评估腹膜关闭在预防二氧化碳（CO₂）气腹后端口部位转移中的作用。
方法
通过向裸鼠腹腔内注射27×10⁶个IGR-OV1细胞系细胞建立异种移植卵巢癌模型。接种7天后，对动物进行CO₂气腹。手术结束时，端口部位随机分为腹膜缝合关闭组（n = 14，A组）和不进行腹膜缝合关闭组（n = 12，B组）。术后7天处死大鼠，切除其端口部位瘢痕。由对伤口闭合类型不知情的病理学家评估肿瘤植入情况。
结果
B组动物发生至少一处端口部位转移的可能性显著高于A组（12只中有7只，即58.3%，而A组14只中有2只，即14.3%）（p = 0.037）。B组出现转移的端口部位比A组更频繁（24个中有8个，即33.3%，而A组28个中有3个，即10.7%）（p = 0.046）。
结论
我们的结果表明腹膜关闭可降低端口部位转移的风险。
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