Colonna Marco, Krug Anne, Cella Marina
Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8118, St Louis, MO 63110, USA.
Curr Opin Immunol. 2002 Jun;14(3):373-9. doi: 10.1016/s0952-7915(02)00349-7.
Interferon-producing cells (IPC) constitute a small population of leukocytes that secrete high levels of type I interferons in response to viruses. Although human IPC have been known for almost two decades, murine IPC have been identified only recently. Furthermore, it has been shown that IPC correspond to the enigmatic 'plasmacytoid cells' identified in human lymph nodes during infections. These breakthroughs have brought IPC to the attention of immunologists for their role in innate immunity and in shaping T cell responses. Here we review recent progress and outstanding questions in the field.
干扰素产生细胞（IPC）是一小群白细胞，它们在受到病毒刺激时会分泌高水平的I型干扰素。尽管人类IPC已被知晓近二十年，但小鼠IPC直到最近才被鉴定出来。此外，研究表明IPC与感染期间在人类淋巴结中发现的神秘“浆细胞样细胞”相对应。这些突破使IPC因其在固有免疫和塑造T细胞反应中的作用而受到免疫学家的关注。在此，我们综述该领域的最新进展和悬而未决的问题。
