Cabanes Didier, Dehoux Pierre, Dussurget Olivier, Frangeul Lionel, Cossart Pascale
Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France.
Trends Microbiol. 2002 May;10(5):238-45. doi: 10.1016/s0966-842x(02)02342-9.
On the basis of the recently determined genome sequence of Listeria monocytogenes, we performed a global analysis of the surface-protein-encoding genes. Only proteins displaying a signal peptide were taken into account. Forty-one genes encoding LPXTG proteins, including the previously known internalin gene family, were detected. Several genes encoding proteins that, like InlB and Ami, possess GW modules that attach them to lipoteichoic acids were also identified. Additionally, the completed genome sequence revealed genes encoding proteins potentially anchored in the cell membrane by a hydrophobic tail as well as genes encoding P60-like proteins and lipoproteins. We describe these families and discuss their putative implications for host-pathogen interactions.
基于最近测定的单核细胞增生李斯特菌基因组序列，我们对表面蛋白编码基因进行了全面分析。仅考虑显示信号肽的蛋白质。检测到41个编码LPXTG蛋白的基因，包括先前已知的内化素基因家族。还鉴定了几个编码蛋白质的基因，这些蛋白质如InlB和Ami，具有将它们附着到脂磷壁酸上的GW模块。此外，完整的基因组序列揭示了编码可能通过疏水尾锚定在细胞膜中的蛋白质的基因，以及编码P60样蛋白和脂蛋白的基因。我们描述了这些家族，并讨论了它们对宿主-病原体相互作用的潜在影响。
