Psychiatr Neurol Med Psychol (Leipz). 1975 Feb;27(2):65-79.
500 chronic schizophrenics (250 men and 250 women) were examined and divided up into two groups according to whether occurrences of psychosis had been proved in the family ('family' cases) or not ('spordic' cases). Considerable discrepancies were found when the two groups were compared. The examination showed the 'sporadic' schizophrenics to be older; their first admission to hospital lay further in the past, they had been in the meantime less frequently discharged, they stayed longer in hospital, more frequently never left hospital after their first admission and showed more rarely fluctuations of the syndrome between two poles. With a more insidious development of the disorder there thus followed a worse prognosis for the sporadic patients than for the familiy patients. The basic discrepancies were significant, for the most part very significant. Sporadic schizophrenics are found more frequently amongst men, family schizophrenics more frequently amongst women. The vast majority of schizophrenics in the families of our test cases were women.
对500名慢性精神分裂症患者(250名男性和250名女性)进行了检查,并根据其家族中是否已证实存在精神病发作情况(“家族性”病例)将他们分为两组。比较这两组时发现了相当大的差异。检查显示,“散发性”精神分裂症患者年龄较大;他们首次入院的时间更早,在此期间出院的频率较低,住院时间更长,首次入院后更频繁地从未出院,且综合征在两极之间波动的情况更少见。随着疾病发展更为隐匿,散发性患者的预后因此比家族性患者更差。这些基本差异具有显著性,在大多数情况下非常显著。散发性精神分裂症患者在男性中更为常见,家族性精神分裂症患者在女性中更为常见。在我们测试病例的家族中,绝大多数精神分裂症患者为女性。