Okoń A, Jurowski P, Goś R
Klinicznego Oddziału Okulistycznego 10 Wojskowego Szpitala Klinicznego z Poliklinika, SPZOZ w Bydgoszczy.
Klin Oczna. 2001;103(4-6):183-6.
To estimate the status of the conjunctival morphology among women treated due to endocrinological or gynecological indications with hormone replacement therapy.
60 women treated with hormonal replacement therapy (HRT) were divided into three groups of examination: group 1 (20 women), treated with HRT after up to 1 year of menopausal symptoms, group 2 (20 women) treated with HRT between 1-5 years of menopausal symptoms, group 3 (20 women) treated with HRT after more than 5 years of menopausal symptoms. The morphology of the conjunctival epithelium was assessed by impressive cytology. The examinations were performed 3, 6, 12 months after HRT treatment. The values obtained before HRT treatment served as control.
The preliminary examinations showed changes of the morphology of conjunctival epithelium in all groups. The longer duration of postmenopausal period, the more advanced morphological changes. In all groups of examinations the HRT has the beneficial influence on the state of conjunctival epithelium morphology.
The age and changes of the hormonal homeostasis have negative influence on conjunctival epithelium morphology among peri- and postmenopausal women. HRT treatment has beneficial effect on the conjunctival epithelium morphology. Our results suggest that hormonal replacement therapy can be suitable for prevention and treatment of postmenopausal conjunctival changes.
评估因内分泌或妇科指征接受激素替代疗法治疗的女性结膜形态状况。
60名接受激素替代疗法（HRT）的女性被分为三组进行检查：第1组（20名女性），在出现绝经症状1年以内开始接受HRT治疗；第2组（20名女性），在出现绝经症状1至5年之间接受HRT治疗；第3组（20名女性），在出现绝经症状5年以上开始接受HRT治疗。通过印象细胞学评估结膜上皮的形态。在HRT治疗后3个月、6个月、12个月进行检查。将HRT治疗前获得的值作为对照。
初步检查显示所有组的结膜上皮形态均有变化。绝经后期持续时间越长，形态变化越明显。在所有检查组中，HRT对结膜上皮形态状况均有有益影响。
年龄和激素稳态变化对围绝经期和绝经后女性的结膜上皮形态有负面影响。HRT治疗对结膜上皮形态有有益作用。我们的结果表明，激素替代疗法可适用于绝经后结膜变化的预防和治疗。
