一类新的亲环蛋白，带有RNA识别基序，在果蝇和人类细胞中与trx/MLL蛋白家族成员相互作用。
A new family of cyclophilins with an RNA recognition motif that interact with members of the trx/MLL protein family in Drosophila and human cells.
作者信息
Anderson Melanie, Fair Keri, Amero Sally, Nelson Stephanie, Harte Peter J, Diaz Manuel O
机构信息
Cancer Center, Department of Medicine, Stritch School of Medicine, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA.
出版信息
Dev Genes Evol. 2002 Apr;212(3):107-13. doi: 10.1007/s00427-002-0213-8. Epub 2002 Mar 6.
A new family of cyclophilins with an RNA recognition motif (RRM) has members in vertebrates, roundworms and flatworms. We have identified a Drosophilacyclophilin, Dcyp33, with a high degree of amino acid sequence identity and similarity with other members of the family. Dcyp33 interacts through its RRM domain with the third PHD finger of trithorax. This interaction is conserved in the human homologues of these proteins, Cyp33 and MLL. Over expression of Dcyp33 in DrosophilaSL1 cells results in down-regulation of AbdominalB Hoxgene expression, mirroring the effect of human Cyp33 on the expression of human HOXgenes.
一类带有RNA识别基序（RRM）的亲环蛋白新家族在脊椎动物、蛔虫和扁形虫中均有成员。我们已经鉴定出一种果蝇亲环蛋白Dcyp33，它与该家族的其他成员具有高度的氨基酸序列同一性和相似性。Dcyp33通过其RRM结构域与三体胸蛋白的第三个植物同源结构域（PHD）指相互作用。这种相互作用在这些蛋白质的人类同源物Cyp33和混合谱系白血病蛋白（MLL）中是保守的。在果蝇SL1细胞中过表达Dcyp33会导致腹部B型同源异型基因（AbdominalB Hoxgene）表达下调，这与人类Cyp33对人类同源框基因（HOXgenes）表达的影响相似。
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